Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.33 |
| ▸ | PRKCQ | Q04759 | 7/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | PDE9A | O76083 | 1/20 | 0.31 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.31 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.31 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.31 |
| ▸ | MERTK | Q12866 | 1/20 | 0.31 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13736418 | 1.00 | KDM4E (0.38) | KDM4EMAPK8PRKCQAURKAPDE9A | |
| SCHEMBL13734429 | 0.90 | KDM4E (0.36) | KDM4EPRKCQPDE9AMERTKLRRK2 | |
| SCHEMBL26104137 | 0.79 | CSNK1A1 (0.45) | MAPK8PRKCQAURKAGABBR2GABBR1 | |
| SCHEMBL30041499 | 0.79 | CSNK1A1 (0.45) | MAPK8PRKCQAURKAGABBR2GABBR1 | |
| SCHEMBL25224701 | 0.78 | PDE9A (0.32) | KDM4EPDE9A | |
| SCHEMBL30461003 | 0.78 | PDE9A (0.32) | KDM4EPDE9A | |
| SCHEMBL22165358 | 0.77 | MAPK8 (0.33) | MAPK8GABBR2GABBR1MAPK9MERTK | |
| SCHEMBL29507863 | 0.77 | MAPK8 (0.33) | MAPK8GABBR2GABBR1MAPK9MERTK | |
| SCHEMBL2480844 | 0.76 | KDM4E (0.45) | KDM4EAURKASYKMEN1GAA | |
| SCHEMBL13737234 | 0.76 | KDM4E (0.36) | KDM4EMAPK8PRKCQMAPK9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4328223-A2 | SUBSTITUTED DIAMINOCARBOXAMIDE AND DIAMINOCARBONITRILE PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | Signal Pharmaceuticals, LLC (US) | 2024-02-28 | — | — | EP | disclosed |