Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperacillin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.76 |
| ▸ | CCKBR | P32239 | 1/20 | 0.76 |
| ▸ | LMNA | P02545 | 3/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | RECQL | P46063 | 3/20 | 0.60 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | TEK | Q02763 | 1/20 | 0.58 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.58 |
| ▸ | CA1 | P00915 | 8/20 | 0.57 |
| ▸ | CA2 | P00918 | 8/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperacillin SCHEMBL3225030 | 1.00 | MEN1 (0.76) | MEN1KMT2ACCKBRLMNAKDM4E | |
| Piperacillin SCHEMBL3233001 | 0.99 | MEN1 (0.77) | MEN1KMT2ACCKBRLMNAKDM4E | |
| Piperacillin SCHEMBL14506140 | 0.99 | MEN1 (0.77) | MEN1KMT2ACCKBRLMNAKDM4E | |
| Piperacillin SCHEMBL13788684 | 0.99 | MEN1 (0.77) | MEN1KMT2ACCKBRLMNAKDM4E | |
| Piperacillin SCHEMBL33894 | 0.99 | MEN1 (0.77) | MEN1KMT2ACCKBRLMNAKDM4E | |
| Piperacillin SCHEMBL24437361 | 0.99 | MEN1 (0.77) | MEN1KMT2ACCKBRLMNAKDM4E | |
| Piperacillin SCHEMBL4486297 | 0.99 | MEN1 (0.77) | MEN1KMT2ACCKBRLMNAKDM4E | |
| Piperacillin SCHEMBL13788683 | 0.99 | MEN1 (0.77) | MEN1KMT2ACCKBRLMNAKDM4E | |
| Piperacillin SCHEMBL11908507 | 0.99 | MEN1 (0.77) | MEN1KMT2ACCKBRLMNAKDM4E | |
| Piperacillin SCHEMBL10477435 | 0.99 | MEN1 (0.77) | MEN1KMT2ACCKBRLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101941980-B | Crystallization purifying and precipitating method of piperacillin acid | JINGDEZHEN FUXIANG PHARMACEUTICAL CO LTD | 2012-02-08 | — | — | CN | claimed |
| CN-101941980-A | Modified crystallization purifying and precipitating method of piperacillin acid | JINGDEZHEN FUXIANG PHARMACEUTICAL CO LTD | 2011-01-12 | — | — | CN | claimed |
| US-20100063273-A1 | NOVEL CRYSTAL OF PIPERACILLIN SODIUM | TOYAMA CHEMICAL CO., LTD (JP) | 2010-03-11 | — | — | US | claimed |
| EP-2128162-A1 | NOVEL CRYSTAL OF PIPERACILLIN SODIUM | Toyama Chemical Co., Ltd. (JP) | 2009-12-02 | — | — | EP | claimed |
| WO-2009131692-A1 | SUBSTRATES FOR DELIVERY OF PHYSIOLOGICALLY ACTIVE AGENTS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA (US) | 2009-10-29 | — | — | WO | claimed |
| CN-107789355-B | Compound pharmaceutical composition containing piperacillin and application thereof | 湘北威尔曼制药股份有限公司 | 2022-04-12 | — | — | CN | disclosed |
| CN-112409381-B | Piperacillin sodium and tazobactam sodium co-amorphous substance and preparation method thereof | 山东安信制药有限公司 | 2022-03-01 | — | — | CN | disclosed |
| CN-113072565-A | Crystallization method of piperacillin | 内蒙古常盛制药有限公司 | 2021-07-06 | — | — | CN | disclosed |
| CN-112409381-A | Piperacillin sodium and tazobactam sodium co-amorphous substance and preparation method thereof | 山东安信制药有限公司 | 2021-02-26 | — | — | CN | disclosed |
| CN-111735892-A | Method for measuring multiple diuretics in animal derived food | 武汉海关技术中心 | 2020-10-02 | — | — | CN | disclosed |
| CN-106714799-A | Method for producing freeze-dried preparation | 泽井制药株式会社 | 2017-05-24 | — | — | CN | disclosed |
| EP-2896625-B1 | COCRYSTAL OF PIPERACILLIN SODIUM AND SULBACTAM SODIUM AND PREPARATION METHOD THEREOF, AS WELL AS PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND USES THEREOF | BEIJING XINTIANYU TECH DEV CO LTD (CN) | 2017-03-01 | — | — | EP | disclosed |
| CN-1802179-A | Injection composition containing piperacillin and tazobactam | WYETH CORP (US) | 2006-07-12 | — | — | CN | disclosed |
| WO-2005074925-A1 | COMPOSITIONS SUBSTANTIALLY FREE OF GALACTOMANNAN CONTAINING PIPERACILLIN AND TAZOBACTAM | WYETH (US) | 2005-08-18 | — | — | WO | disclosed |
| US-20050171077-A1 | Compositions containing piperacillin and tazobactam | WYETH (US) | 2005-08-04 | — | — | US | disclosed |
| US-6900184-B2 | Compositions containing pipercillin and tazobactam useful for injection | WYETH HOLDINGS CORPORATION (US) | 2005-05-31 | — | — | US | disclosed |
| WO-2004098643-A1 | COMPOSITIONS CONTAINING PIPERACILLIN AND TAZOBACTAM USEFUL FOR INJECTION | WYETH HOLDINGS CORPORATION (US) | 2004-11-18 | — | — | WO | disclosed |
| WO-2004091666-A1 | COMPOSITIONS CONTAINING PIPERACILLIN AND TAZOBACTAM USEFUL FOR INJECTION | WYETH HOLDINGS CORPORATION (US) | 2004-10-28 | — | — | WO | disclosed |
| EP-1468697-A1 | Compositions containing piperacillin and tazobactam useful for injection | Wyeth Holdings Corporation (US) | 2004-10-20 | — | — | EP | disclosed |
| US-20040204372-A1 | Compositions containing pipercillin and tazobactam sodium useful for injection | WYETH HOLDINGS CORPORATION | 2004-10-14 | — | — | US | disclosed |