Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 11/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 10/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 9/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 9/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.52 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2116590 | 0.89 | HDAC6 (0.56) | HDAC6HDAC8HDAC1HDAC2HDAC10 | |
| SCHEMBL2118972 | 0.85 | HDAC6 (0.51) | HDAC6HDAC8HDAC1HDAC2HDAC10 | |
| SCHEMBL2117375 | 0.85 | HDAC6 (0.60) | HDAC6HDAC8HDAC1HDAC2HDAC10 | |
| SCHEMBL2611239 | 0.85 | HDAC6 (0.60) | HDAC6HDAC8HDAC1HDAC2HDAC10 | |
| SCHEMBL1993113 | 0.84 | HDAC8 (0.71) | HDAC6HDAC8HDAC1HDAC2HDAC10 | |
| SCHEMBL2611339 | 0.84 | HDAC6 (0.74) | HDAC6HDAC8HDAC1HDAC2HDAC10 | |
| SCHEMBL2120228 | 0.84 | MAPT (0.48) | HDAC6HDAC8HDAC1HDAC2HDAC10 | |
| SCHEMBL17545581 | 0.84 | HDAC6 (0.46) | HDAC6HDAC8HDAC1HDAC2HDAC10 | |
| SCHEMBL10285120 | 0.84 | PLAU (0.53) | HDAC6HDAC8HDAC1HDAC2HDAC10 | |
| SCHEMBL2611281 | 0.84 | EPHX2 (0.48) | HDAC6HDAC8HDAC1HDAC2HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8765773-B2 | Substituted hydroxamic acids and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-07-01 | — | — | US | disclosed |
| US-8765773-B2 | Substituted hydroxamic acids and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-07-01 | — | — | US | disclosed |
| WO-2012054332-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-04-26 | — | — | WO | disclosed |
| US-20120094997-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-04-19 | — | — | US | disclosed |
| US-20120094997-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120094997-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | HDAC6, HDAC1, HDAC5 | HDAC6 1/4885HDAC8 14/4885HDAC1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.