Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 3/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 14/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 11/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 5/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.45 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.45 |
| ▸ | PLG | P00747 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2116590 | 0.87 | HDAC6 (0.56) | HDAC6HDAC1HDAC8HDAC2HDAC10 | |
| SCHEMBL2611357 | 0.87 | EGLN1 (0.50) | HDAC6HDAC1HDAC8HDAC2HDAC10 | |
| SCHEMBL17545581 | 0.87 | HDAC6 (0.46) | PLAUHDAC6HDAC1HDAC8HDAC2 | |
| SCHEMBL2120228 | 0.87 | MAPT (0.48) | HDAC6HDAC1HDAC8HDAC2HDAC10 | |
| SCHEMBL2611281 | 0.87 | EPHX2 (0.48) | HDAC6HDAC1HDAC8HDAC2HDAC10 | |
| SCHEMBL2611535 | 0.86 | PLAU (0.52) | PLAUPLG | |
| Hydrochloric Acid SCHEMBL2118697 | 0.85 | PLAU (0.51) | PLAUPLG | |
| SCHEMBL2611202 | 0.84 | HDAC6 (0.56) | HDAC6HDAC1HDAC8HDAC2HDAC10 | |
| SCHEMBL15832819 | 0.84 | LMNA (0.52) | HDAC6HDAC1HDAC8HDAC2HDAC10 | |
| SCHEMBL2116360 | 0.84 | ATM (0.55) | HDAC6HDAC1HDAC8HDAC2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054332-A1 | SUBSTITUTED HYDROXAMIC ACIDS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2012-04-26 | — | — | WO | disclosed |