Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 5/20 | 0.44 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30546146 | 1.00 | MAPT (0.52) | MAPTKMT2ASMN1; SMN2ABL1GSK3B | |
| SCHEMBL4979085 | 0.84 | KMT2A (0.57) | MAPTKMT2ASMN1; SMN2ABL1GSK3B | |
| Hydrochloric Acid SCHEMBL27769986 | 0.83 | KMT2A (0.56) | MAPTKMT2ASMN1; SMN2ABL1GSK3B | |
| SCHEMBL9131695 | 0.77 | KDM4E (0.46) | MAPTKMT2ASMN1; SMN2MEN1HTT | |
| SCHEMBL20189743 | 0.75 | GAA (0.43) | KMT2ASMN1; SMN2ABL1HTTALDH1A1 | |
| SCHEMBL30448357 | 0.75 | GAA (0.43) | KMT2ASMN1; SMN2ABL1HTTALDH1A1 | |
| SCHEMBL7955683 | 0.75 | RAB9A (0.45) | MAPTKMT2ASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL18395352 | 0.74 | GSK3B (0.59) | MAPTKMT2ASMN1; SMN2ABL1GSK3B | |
| SCHEMBL10025629 | 0.71 | KMT2A (0.42) | MAPTKMT2ASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL1366867 | 0.71 | XPO1 (0.43) | MAPTKMT2ASMN1; SMN2GSK3BGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192989-A2 | PHTHALAZINONE COMPOUNDS AS PARP7 INHIBITORS | AZKARRA THERAPEUTICS, INC. (US) | 2023-10-05 | — | — | WO | disclosed |
| WO-2023192989-A2 | PHTHALAZINONE COMPOUNDS AS PARP7 INHIBITORS | AZKARRA THERAPEUTICS, INC. (US) | 2023-10-05 | — | — | WO | disclosed |