Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ticagrelor. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RY12 known ✓ | Q9H244 | 16/20 | 1.00 |
| ▸ | PGR | P06401 | 1/20 | 1.00 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 1/20 | 1.00 |
| ▸ | DRD1 | P21728 | 1/20 | 1.00 |
| ▸ | TBXA2R | P21731 | 1/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 1/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 1/20 | 1.00 |
| ▸ | FPR3 | P25089 | 1/20 | 1.00 |
| ▸ | PDE4A | P27815 | 1/20 | 1.00 |
| ▸ | GPR183 | P32249 | 1/20 | 1.00 |
| ▸ | DRD3 | P35462 | 1/20 | 1.00 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 1/20 | 1.00 |
| ▸ | PDE3A | Q14432 | 1/20 | 1.00 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 1.00 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 1.00 |
| ▸ | P2RY13 | Q9BPV8 | 1/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ticagrelor SCHEMBL16296587 | 1.00 | P2RY12 (1.00) | P2RY12PGRADORA3CHRM1DRD1 | |
| Ticagrelor SCHEMBL17679491 | 1.00 | P2RY12 (1.00) | P2RY12PGRADORA3CHRM1DRD1 | |
| Ticagrelor SCHEMBL17244412 | 1.00 | P2RY12 (1.00) | P2RY12PGRADORA3CHRM1DRD1 | |
| Ticagrelor SCHEMBL20208100 | 1.00 | P2RY12 (1.00) | P2RY12PGRADORA3CHRM1DRD1 | |
| Ticagrelor SCHEMBL14566034 | 1.00 | P2RY12 (1.00) | P2RY12PGRADORA3CHRM1DRD1 | |
| Ticagrelor SCHEMBL24418222 | 1.00 | P2RY12 (1.00) | P2RY12PGRADORA3CHRM1DRD1 | |
| Ticagrelor SCHEMBL17679477 | 1.00 | P2RY12 (1.00) | P2RY12PGRADORA3CHRM1DRD1 | |
| Ticagrelor SCHEMBL22375060 | 1.00 | P2RY12 (1.00) | P2RY12PGRADORA3CHRM1DRD1 | |
| Ticagrelor SCHEMBL20866157 | 1.00 | P2RY12 (1.00) | P2RY12PGRADORA3CHRM1DRD1 | |
| Ticagrelor SCHEMBL18674056 | 1.00 | P2RY12 (1.00) | P2RY12PGRADORA3CHRM1DRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8563755-B2 | Process for preparing [1S-[1-α, 2-α, 3-β(1S*,2R*) 5-β]]-3-[7-[2-(3,4-difluorophenyl)-cyclopropylamino]-5-(propylthio)-3H-1,2,3-triazolo [4,5-d] pyrimidin-3-yl]-5-(2-hydroxyethoxy) cyclopentane-1,2-diol and to its intermediates | ASTRAZENECA AB (SE) | 2013-10-22 | — | — | US | disclosed |
| US-8563755-B2 | Process for preparing [1S-[1-α, 2-α, 3-β(1S*,2R*) 5-β]]-3-[7-[2-(3,4-difluorophenyl)-cyclopropylamino]-5-(propylthio)-3H-1,2,3-triazolo [4,5-d] pyrimidin-3-yl]-5-(2-hydroxyethoxy) cyclopentane-1,2-diol and to its intermediates | ASTRAZENECA AB (SE) | 2013-10-22 | — | — | US | disclosed |
| US-8273879-B2 | Triazolo pyrimidine compounds | ASTRAZENECA AB (SE) | 2012-09-25 | — | — | US | disclosed |
| US-8273879-B2 | Triazolo pyrimidine compounds | ASTRAZENECA AB (SE) | 2012-09-25 | — | — | US | disclosed |
| US-20120101274-A1 | Process For Preparing [1S-[1-alpha, 2-alpha, 3-beta (1S*,2R*) 5-beta]]-3-[7-[2-(3,4-difluorophenyl)-cyclopropylamino]-5-(propylthio)-3H-1,2,3-triazolo [4,5-d] pyrimidin-3-yl]-5-(2-hydroxyethoxy) cyclopentane-1,2-diol And To Its Intermediates | ASTRAZENECA AB (SE) | 2012-04-26 | — | — | US | disclosed |
| US-20120101274-A1 | Process For Preparing [1S-[1-alpha, 2-alpha, 3-beta (1S*,2R*) 5-beta]]-3-[7-[2-(3,4-difluorophenyl)-cyclopropylamino]-5-(propylthio)-3H-1,2,3-triazolo [4,5-d] pyrimidin-3-yl]-5-(2-hydroxyethoxy) cyclopentane-1,2-diol And To Its Intermediates | ASTRAZENECA AB (SE) | 2012-04-26 | — | — | US | disclosed |
| US-20110218330-A1 | Novel triazolo pyrimidine compounds | ASTRAZENECA AB (SE) | 2011-09-08 | — | — | US | disclosed |
| US-20110218330-A1 | Novel triazolo pyrimidine compounds | ASTRAZENECA AB (SE) | 2011-09-08 | — | — | US | disclosed |
| US-20100004444-A1 | Novel Triazolo pyrimidine compounds | ASTRAZENECA AB (SE) | 2010-01-07 | — | — | US | disclosed |
| US-20100004444-A1 | Novel Triazolo pyrimidine compounds | ASTRAZENECA AB (SE) | 2010-01-07 | — | — | US | disclosed |
| US-20080234481-A1 | Novel triazolo pyrimidine compounds | ASTRAZENECA AB (SE) | 2008-09-25 | — | — | US | disclosed |
| US-20080234481-A1 | Novel triazolo pyrimidine compounds | ASTRAZENECA AB (SE) | 2008-09-25 | — | — | US | disclosed |
| US-7381828-B2 | Triazolo pyrimidine compounds | AstraZēneca AB (SE) | 2008-06-03 | — | — | US | disclosed |
| US-7381828-B2 | Triazolo pyrimidine compounds | AstraZēneca AB (SE) | 2008-06-03 | — | — | US | disclosed |
| US-20070049755-A1 | Novel triazolo pyrimidine compounds | ASTRAZENECA AB (SE) | 2007-03-01 | — | — | US | disclosed |
| US-20070049755-A1 | Novel triazolo pyrimidine compounds | ASTRAZENECA AB (SE) | 2007-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070049755-A1 | Novel triazolo pyrimidine compounds | TYMS, TYMP, DPYD | P2RY12 191/4885PGR 2439/4885ADORA3 320/4885 |
| US-20080234481-A1 | Novel triazolo pyrimidine compounds | TYMS, TYMP, DPYD | P2RY12 191/4885PGR 2439/4885ADORA3 320/4885 |
| US-20120101274-A1 | Process For Preparing [1S-[1-alpha, 2-alpha, 3-beta (1S*,2R*) 5-beta]]-3-[7-[2-(3,4-difluorophenyl)-cyclopropylamino]-5-(propylthio)-3H-1,2,3-triazolo [4,5-d] pyrimidin-3-yl]-5-(2-hydroxyethoxy) cyclopentane-1,2-diol And To Its Intermediates | DHPS, CYP1B1, DEGS1 | P2RY12 3827/4885PGR 3830/4885ADORA3 1700/4885 |
| US-20100004444-A1 | Novel Triazolo pyrimidine compounds | TYMS, TYMP, DPYD | P2RY12 191/4885PGR 2439/4885ADORA3 320/4885 |
| US-20110218330-A1 | Novel triazolo pyrimidine compounds | TYMS, TYMP, DPYD | P2RY12 191/4885PGR 2439/4885ADORA3 320/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.