Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 0.43 |
| ▸ | JAK3 | P52333 | 6/20 | 0.43 |
| ▸ | JAK1 | P23458 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.38 |
| ▸ | WDR5 | P61964 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29968129 | 1.00 | JAK2 (0.43) | JAK2JAK3JAK1ALDH1A1MAPK1 | |
| SCHEMBL29493167 | 0.93 | ALDH1A1 (0.47) | JAK2JAK3JAK1ALDH1A1MAPK1 | |
| SCHEMBL26130393 | 0.93 | ALDH1A1 (0.47) | JAK2JAK3JAK1ALDH1A1MAPK1 | |
| SCHEMBL22941968 | 0.90 | ALDH1A1 (0.43) | JAK2JAK3JAK1ALDH1A1MAPK1 | |
| SCHEMBL26131983 | 0.81 | MAPT (0.51) | ALDH1A1MAPK1HTTOPRK1 | |
| SCHEMBL29969961 | 0.81 | MAPT (0.51) | ALDH1A1MAPK1HTTOPRK1 | |
| SCHEMBL29969671 | 0.81 | ALDH1A1 (0.40) | JAK2JAK3JAK1ALDH1A1MAPK1 | |
| SCHEMBL26127971 | 0.81 | ALDH1A1 (0.40) | JAK2JAK3JAK1ALDH1A1MAPK1 | |
| SCHEMBL29968881 | 0.80 | ALDH1A1 (0.44) | ALDH1A1MAPK1HTTOPRK1 | |
| SCHEMBL26131943 | 0.80 | ALDH1A1 (0.44) | ALDH1A1MAPK1HTTOPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4327877-A2 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRad Therapeutics, Inc. (US) | 2024-02-28 | — | — | EP | disclosed |
| EP-4327877-A2 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRad Therapeutics, Inc. (US) | 2024-02-28 | — | — | EP | disclosed |
| EP-3784671-B1 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRAD THERAPEUTICS INC (US) | 2023-10-11 | — | — | EP | disclosed |
| EP-3784671-B1 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRAD THERAPEUTICS INC (US) | 2023-10-11 | — | — | EP | disclosed |