Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT14 | O95848 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 11/20 | 0.37 |
| ▸ | JAK3 | P52333 | 11/20 | 0.37 |
| ▸ | JAK1 | P23458 | 6/20 | 0.37 |
| ▸ | BTK | Q06187 | 4/20 | 0.35 |
| ▸ | TYK2 | P29597 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 2/20 | 0.35 |
| ▸ | ITK | Q08881 | 1/20 | 0.35 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30582534 | 1.00 | NUDT14 (0.37) | NUDT14JAK2JAK3JAK1BTK | |
| SCHEMBL30582524 | 0.92 | NUDT14 (0.41) | NUDT14JAK2JAK3JAK1BTK | |
| SCHEMBL30582522 | 0.90 | FGFR2 (0.36) | NUDT14JAK2JAK3JAK1BTK | |
| SCHEMBL26105835 | 0.87 | SRC (0.37) | EGFR | |
| SCHEMBL30582632 | 0.87 | SRC (0.37) | EGFR | |
| SCHEMBL30582532 | 0.87 | BTK (0.37) | NUDT14JAK2JAK3JAK1BTK | |
| SCHEMBL30582502 | 0.86 | FGFR1 (0.39) | NUDT14JAK2JAK3JAK1BTK | |
| SCHEMBL26588835 | 0.86 | FGFR2 (0.39) | NUDT14JAK2JAK3JAK1BTK | |
| SCHEMBL26588196 | 0.86 | NUDT14 (0.39) | NUDT14JAK2JAK3JAK1BTK | |
| SCHEMBL30582516 | 0.85 | FGFR2 (0.43) | ITKFGFR2FGFR1FGFR4FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192502-A1 | SPIROBICYCLIC COMPOUNDS | ACERAND THERAPEUTICS (USA) LIMITED (US) | 2023-10-05 | — | — | WO | disclosed |
| WO-2023192502-A1 | SPIROBICYCLIC COMPOUNDS | ACERAND THERAPEUTICS (USA) LIMITED (US) | 2023-10-05 | — | — | WO | disclosed |