Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 3/20 | 0.44 |
| ▸ | CA12 | O43570 | 2/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | OGA | O60502 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16473964 | 1.00 | CA9 (0.44) | CA9CA12CA1CA2TSHR | |
| SCHEMBL10819145 | 0.89 | CA9 (0.37) | CA9CA12CA1CA2TSHR | |
| SCHEMBL24337169 | 0.85 | CA9 (0.46) | CA9CA12CA1CA2TSHR | |
| SCHEMBL11249103 | 0.84 | CA9 (0.49) | CA9CA12CA1CA2TSHR | |
| SCHEMBL2614790 | 0.83 | CA9 (0.45) | CA9CA12CA1CA2TSHR | |
| SCHEMBL30236727 | 0.83 | CA9 (0.45) | CA9CA12CA1CA2TSHR | |
| SCHEMBL12975857 | 0.82 | CA9 (0.51) | CA9CA12CA1CA2TSHR | |
| SCHEMBL23563178 | 0.82 | CA9 (0.51) | CA9CA12CA1CA2TSHR | |
| SCHEMBL14022962 | 0.82 | CA9 (0.51) | CA9CA12CA1CA2TSHR | |
| SCHEMBL16620453 | 0.82 | CA9 (0.51) | CA9CA12CA1CA2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163551-B2 | Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation | SEATTLE GENETICS, INC. (US) | 2012-04-24 | — | — | US | disclosed |
| US-20090317869-A1 | METHODS AND COMPOSITIONS FOR MAKING ANTIBODIES AND ANTIBODY DERIVATIVES WITH REDUCED CORE FUCOSYLATION | SEATTLE GENETICS, INC. (US) | 2009-12-24 | — | — | US | disclosed |