Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 12/20 | 0.63 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.63 |
| ▸ | GSPT1 | P15170 | 2/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.63 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.62 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.60 |
| ▸ | IKZF2 | Q9UKS7 | 6/20 | 0.59 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.54 |
| ▸ | MAP1LC3B | Q9GZQ8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1403628 | 0.92 | CRBN (0.66) | CRBNDDB1GSPT1CYP2C19KCNH2 | |
| SCHEMBL26148525 | 0.92 | CRBN (0.64) | CRBNDDB1GSPT1CYP2C19KCNH2 | |
| SCHEMBL1413563 | 0.92 | CRBN (0.74) | CRBNDDB1GSPT1CYP2C19KCNH2 | |
| SCHEMBL13578966 | 0.92 | CRBN (0.62) | CRBNDDB1GSPT1CYP2C19KCNH2 | |
| SCHEMBL1403675 | 0.92 | CRBN (0.62) | CRBNDDB1GSPT1CYP2C19KCNH2 | |
| SCHEMBL26148713 | 0.91 | CRBN (0.61) | CRBNDDB1GSPT1CYP2C19KCNH2 | |
| SCHEMBL1403669 | 0.90 | CRBN (0.65) | CRBNDDB1GSPT1CYP2C19KCNH2 | |
| SCHEMBL1403618 | 0.90 | CRBN (0.62) | CRBNDDB1GSPT1CYP2C19KCNH2 | |
| SCHEMBL16381535 | 0.90 | CRBN (0.62) | CRBNDDB1GSPT1CYP2C19KCNH2 | |
| SCHEMBL15841617 | 0.90 | CRBN (0.62) | CRBNDDB1GSPT1CYP2C19KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118201917-A | Compound with degradation GSPT1 activity and application thereof | 上海美志医药科技有限公司 | 2024-06-14 | — | — | CN | disclosed |
| WO-2023078410-A1 | COMPOUND HAVING ACTIVITY OF DEGRADING GSPT1 AND APPLICATION THEREOF | 上海美志医药科技有限公司 | 2023-05-11 | — | — | WO | disclosed |
| WO-2023078410-A1 | COMPOUND HAVING ACTIVITY OF DEGRADING GSPT1 AND APPLICATION THEREOF | 上海美志医药科技有限公司 | 2023-05-11 | — | — | WO | disclosed |
| CN-116082301-A | Compound with GSPT1 degradation activity and application thereof | 上海美志医药科技有限公司 | 2023-05-09 | — | — | CN | disclosed |