Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 12/20 | 0.62 |
| ▸ | GSPT1 | P15170 | 4/20 | 0.62 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.62 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.60 |
| ▸ | IKZF2 | Q9UKS7 | 8/20 | 0.53 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20920064 | 0.95 | CRBN (0.60) | CRBNGSPT1DDB1IKZF3CYP2C19 | |
| SCHEMBL1403628 | 0.91 | CRBN (0.66) | CRBNGSPT1DDB1IKZF3CYP2C19 | |
| SCHEMBL26148387 | 0.90 | CRBN (0.63) | CRBNGSPT1DDB1IKZF3CYP2C19 | |
| SCHEMBL1403648 | 0.90 | CRBN (0.60) | CRBNGSPT1DDB1IKZF3CYP2C19 | |
| SCHEMBL13578966 | 0.89 | CRBN (0.62) | CRBNGSPT1DDB1IKZF3CYP2C19 | |
| SCHEMBL26148525 | 0.89 | CRBN (0.64) | CRBNGSPT1DDB1IKZF3CYP2C19 | |
| SCHEMBL1413563 | 0.89 | CRBN (0.74) | CRBNGSPT1DDB1IKZF3CYP2C19 | |
| SCHEMBL1403675 | 0.89 | CRBN (0.62) | CRBNGSPT1DDB1IKZF3CYP2C19 | |
| SCHEMBL4452280 | 0.89 | CRBN (0.66) | CRBNGSPT1DDB1IKZF3CYP2C19 | |
| SCHEMBL4451051 | 0.89 | CRBN (0.63) | CRBNGSPT1DDB1IKZF3CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150005303-A1 | 5-SUBSTITUTED ISOINDOLINE COMPOUNDS | CELGENE CORPORATION | 2015-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150005303-A1 | 5-SUBSTITUTED ISOINDOLINE COMPOUNDS | CYP3A5, CYP3A7, CYP3A4 | CRBN 4610/4885GSPT1 1959/4885DDB1 3649/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.