Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.65 |
| ▸ | APAF1 | O14727 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 1/20 | 0.65 |
| ▸ | APEX1 | P27695 | 1/20 | 0.65 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.65 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.65 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.65 |
| ▸ | MMP2 | P08253 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.52 |
| ▸ | CNR1 | P21554 | 1/20 | 0.52 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.47 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13285180 | 0.91 | TDP1 (0.72) | TDP1APAF1LMNATSHRAPEX1 | |
| SCHEMBL9481589 | 0.83 | TDP1 (0.72) | TDP1APAF1LMNATSHRAPEX1 | |
| SCHEMBL9481568 | 0.83 | TDP1 (0.72) | TDP1APAF1LMNATSHRAPEX1 | |
| SCHEMBL9481983 | 0.81 | TDP1 (0.74) | TDP1APAF1LMNATSHRAPEX1 | |
| SCHEMBL9481985 | 0.81 | TDP1 (0.74) | TDP1APAF1LMNATSHRAPEX1 | |
| SCHEMBL11040869 | 0.80 | TDP1 (0.69) | TDP1APAF1LMNATSHRAPEX1 | |
| SCHEMBL11040874 | 0.80 | TDP1 (0.69) | TDP1APAF1LMNATSHRAPEX1 | |
| SCHEMBL10670865 | 0.80 | TDP1 (0.76) | TDP1APAF1LMNATSHRAPEX1 | |
| SCHEMBL11044311 | 0.80 | TDP1 (0.74) | TDP1APAF1LMNATSHRAPEX1 | |
| SCHEMBL10670855 | 0.80 | TDP1 (0.76) | TDP1APAF1LMNATSHRAPEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120095217-A1 | FLUORINE CONTAINING COMPOUNDS AND METHODS OF USE THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2012-04-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120095217-A1 | FLUORINE CONTAINING COMPOUNDS AND METHODS OF USE THEREOF | FLI1, CDC73, FOS | TDP1 1090/4885APAF1 798/4885LMNA 1375/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.