SCHEMBL26160482

SCHEMBL26160482

Cc1c(OC(c2ccc(C#N)cc2)c2ccc([C@H](N)O)cc2)ccc2c1OCCC2=O

nearest known ligand 0.37

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
MAOB P27338 1/20 0.37
LTB4R Q15722 1/20 0.32
LTB4R2 Q9NPC1 1/20 0.32
LMNA P02545 1/20 0.32
MAPT P10636 1/20 0.32
GRM5 P41594 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26160493 1.00 MAOB (0.37) MAOBLTB4RLTB4R2LMNAMAPT
SCHEMBL26160488 1.00 MAOB (0.37) MAOBLTB4RLTB4R2LMNAMAPT
SCHEMBL26160495 0.91 GRM5 (0.40) MAOBLTB4RLTB4R2GRM5
SCHEMBL26160500 0.91 GRM5 (0.40) MAOBLTB4RLTB4R2GRM5
SCHEMBL23882901 0.89 MAOB (0.39) MAOBLTB4RLTB4R2LMNAMAPT
SCHEMBL30251356 0.89 MAOB (0.39) MAOBLTB4RLTB4R2LMNAMAPT
SCHEMBL23905916 0.89 PARP15 (0.38) MAOBLTB4RLTB4R2LMNAMAPT
SCHEMBL23882849 0.89 PARP15 (0.38) MAOBLTB4RLTB4R2LMNAMAPT
SCHEMBL32675550 0.89 PARP15 (0.38) MAOBLTB4RLTB4R2LMNAMAPT
SCHEMBL23905886 0.89 PARP15 (0.38) MAOBLTB4RLTB4R2LMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230150985-A1 INHIBITORS OF ANTIGEN PRESENTATION BY HLA-DR JANSSEN PHARMACEUTICA NV (BE) 2023-05-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230150985-A1 INHIBITORS OF ANTIGEN PRESENTATION BY HLA-DR HLA-DRB1, CD74, HLA-C MAOB 1451/4885LTB4R 562/4885LTB4R2 644/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.