Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 6/20 | 0.37 |
| ▸ | MAP4K1 | Q92918 | 6/20 | 0.36 |
| ▸ | TNK2 | Q07912 | 3/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.35 |
| ▸ | FLT4 | P35916 | 1/20 | 0.35 |
| ▸ | ULK1 | O75385 | 1/20 | 0.35 |
| ▸ | ULK2 | Q8IYT8 | 1/20 | 0.35 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.35 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.35 |
| ▸ | PLK1 | P53350 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25210979 | 0.88 | MAP4K1 (0.40) | MAP4K1PTK2FLT4CDC7DBF4 | |
| SCHEMBL30412210 | 0.88 | MAP4K1 (0.40) | MAP4K1PTK2FLT4CDC7DBF4 | |
| SCHEMBL30412660 | 0.88 | MERTK (0.38) | PTK2 | |
| SCHEMBL25208657 | 0.88 | MERTK (0.38) | PTK2 | |
| SCHEMBL30412558 | 0.86 | ULK1 (0.51) | TNK2PTK2FLT4ULK1ULK2 | |
| SCHEMBL25205428 | 0.86 | ULK1 (0.51) | TNK2PTK2FLT4ULK1ULK2 | |
| SCHEMBL26164230 | 0.84 | MAP4K1 (0.42) | LRRK2MAP4K1TNK2PTK2ULK1 | |
| SCHEMBL25197714 | 0.81 | MAP4K1 (0.44) | LRRK2MAP4K1TNK2PTK2MAP4K3 | |
| SCHEMBL30412113 | 0.81 | MAP4K1 (0.44) | LRRK2MAP4K1TNK2PTK2MAP4K3 | |
| SCHEMBL25216242 | 0.80 | MAP4K1 (0.41) | MAP4K1TNK2PTK2FLT4MAP4K3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023215494-A1 | THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF | ERASCA, INC. (US) | 2023-11-09 | — | — | WO | disclosed |
| WO-2023087027-A1 | THIOPHENE ULK1/2 INHIBITORS AND THEIR USE THEREOF | ERASCA, INC. (US) | 2023-05-19 | — | — | WO | disclosed |