SCHEMBL26167946

SCHEMBL26167946

CN(C)c1c(C(=O)O)cnc2c(-c3cc(F)cc(F)c3F)c(F)ccc12

nearest known ligand 0.33

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ DHODH Q02127 2/20 0.33
▸ GRIN2B Q13224 7/20 0.32
▸ EIF4E P06730 1/20 0.32
▸ PRKAG1 P54619 1/20 0.31
▸ PRKAA1 Q13131 1/20 0.31
▸ PRKAB1 Q9Y478 1/20 0.31
▸ HPGD P15428 1/20 0.31
▸ EPRS1 P07814 1/20 0.31
▸ CES2 O00748 2/20 0.30
▸ CES1 P23141 2/20 0.30
▸ KDM4E B2RXH2 2/20 0.30
▸ ASPH Q12797 2/20 0.30
▸ KDM8 Q8N371 2/20 0.30
▸ TDO2 P48775 1/20 0.30
▸ PTGER1 P34995 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26167943 0.86 KMT2A (0.40) —
SCHEMBL30207758 0.86 KMT2A (0.40) —
SCHEMBL30207766 0.84 HAVCR2 (0.35) DHODHGRIN2BEIF4EPRKAG1PRKAA1
SCHEMBL26167910 0.84 HAVCR2 (0.35) DHODHGRIN2BEIF4EPRKAG1PRKAA1
SCHEMBL26167955 0.82 GABRP (0.33) DHODHGRIN2BEIF4EEPRS1CES2
SCHEMBL26167940 0.81 — —
SCHEMBL29281905 0.81 EIF4E (0.33) DHODHEIF4ECES2CES1KDM4E
SCHEMBL30207757 0.78 HAVCR2 (0.41) DHODHGRIN2BPRKAG1PRKAA1PRKAB1
SCHEMBL26167974 0.78 HAVCR2 (0.41) DHODHGRIN2BPRKAG1PRKAA1PRKAB1
SCHEMBL29281920 0.77 DHODH (0.33) DHODHEIF4ECES2CES1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230174492-A1 SUBSTITUTED CONDENSED AZINES AS ANTHELMINTIC COMPOUNDS ELANCO ANIMAL HEALTH GMBH (DE) 2023-06-08 — — US disclosed
US-20230174492-A1 SUBSTITUTED CONDENSED AZINES AS ANTHELMINTIC COMPOUNDS ELANCO ANIMAL HEALTH GMBH (DE) 2023-06-08 — — US disclosed
US-20230174492-A1 SUBSTITUTED CONDENSED AZINES AS ANTHELMINTIC COMPOUNDS ELANCO ANIMAL HEALTH GMBH (DE) 2023-06-08 — — US disclosed
EP-4132911-A1 SUBSTITUTED CONDENSED AZINES AS ANTHELMINTIC COMPOUNDS Bayer Animal Health GmbH (DE) 2023-02-15 — — EP disclosed
CN-115667221-A Substituted fused oxazines as insect repellent compounds 拜耳动物保健有限责任公司 2023-01-31 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230174492-A1 SUBSTITUTED CONDENSED AZINES AS ANTHELMINTIC COMPOUNDS H1-5, H1-10, H1-0 DHODH 967/4885GRIN2B 4204/4885EIF4E 3941/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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