Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2289352 | 0.82 | CYP1A2 (0.34) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2B6 | |
| SCHEMBL268965 | 0.78 | CYP1A2 (0.50) | ALDH1A1MAPTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL261688 | 0.78 | CYP1A2 (0.50) | ALDH1A1MAPTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL2289369 | 0.74 | ALDH1A1 (0.34) | ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL2293887 | 0.73 | ALDH1A1 (0.33) | ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL2290136 | 0.70 | ALDH1A1 (0.33) | ALDH1A1MAPK1SMN1; SMN2CYP1A2CYP3A4 | |
| SCHEMBL14285925 | 0.68 | ALDH1A1 (0.45) | MEN1NPC1ALDH1A1MAPTMAPK1 | |
| SCHEMBL1801435 | 0.68 | USP2 (0.39) | ALDH1A1SMN1; SMN2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL21524054 | 0.68 | ALDH1A1 (0.38) | ALDH1A1 | |
| SCHEMBL2289354 | 0.68 | CYP1A2 (0.47) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2069322-B1 | THIOPHENE DERIVATIVES AS S1P1/EDG1 RECEPTOR AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2012-09-12 | — | — | EP | disclosed |
| US-8133910-B2 | Thiophene derivatives as S1P1/EDGE1 receptor agonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-03-13 | — | — | US | disclosed |
| US-20100048648-A1 | Thiophene derivatives as S1P1/EDGE1 receptor agonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2010-02-25 | — | — | US | disclosed |
| EP-2069322-A2 | THIOPHENE DERIVATIVES AS S1P1/EDG1 RECEPTOR AGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2009-06-17 | — | — | EP | disclosed |
| WO-2008029306-A2 | THIOPHENE DERIVATIVES AS S1P1/EDG1 RECEPTOR AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2008-03-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100048648-A1 | Thiophene derivatives as S1P1/EDGE1 receptor agonists | S1PR1, S1PR3, S1PR2 | PTGS1 423/4885PTGS2 1168/4885MEN1 1296/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.