Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 9/20 | 0.52 |
| ▸ | MAPK12 | P53778 | 8/20 | 0.52 |
| ▸ | MAPK11 | Q15759 | 8/20 | 0.52 |
| ▸ | ABL1 | P00519 | 2/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.42 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5547951 | 0.92 | MAPK14 (0.51) | MAPK14MAPK13MAPK12MAPK11ABL1 | |
| Hydrochloric Acid SCHEMBL2081549 | 0.91 | MAPK14 (0.51) | MAPK14MAPK13MAPK12MAPK11ABL1 | |
| SCHEMBL2617024 | 0.83 | ABL1 (0.69) | MAPK14MAPK11ABL1BRAF | |
| SCHEMBL2083343 | 0.83 | ABL1 (0.69) | MAPK14MAPK11ABL1BRAF | |
| SCHEMBL2080268 | 0.76 | ABL1 (0.57) | MAPK14MAPK13MAPK12MAPK11ABL1 | |
| SCHEMBL2083128 | 0.76 | ABL1 (0.69) | MAPK14MAPK13MAPK12MAPK11ABL1 | |
| SCHEMBL2084884 | 0.76 | MAPK14 (0.54) | MAPK14MAPK13MAPK12MAPK11ABL1 | |
| SCHEMBL2083747 | 0.73 | MAPK14 (0.59) | MAPK14MAPK13MAPK12MAPK11ABL1 | |
| SCHEMBL2082895 | 0.73 | MAPK14 (0.46) | MAPK14MAPK13MAPK12MAPK11ABL1 | |
| SCHEMBL2084383 | 0.73 | ABL1 (0.59) | MAPK14MAPK13MAPK12MAPK11ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163756-B2 | For example,1-(3-t-butyl-1- (1,2,3,4-tetrahydro- isoquinolin-6-yl)-1H- pyrazol-5-yl)-3-(3- cyanophenyl)urea; for treatment of mammalian cancers and inflammatory diseases including rheumatoid arthritis, retinopathies | DECIPHERA PHARMACEUTICALS, LLC (US) | 2012-04-24 | — | — | US | disclosed |
| US-20080113967-A1 | ENZYME MODULATORS AND TREATMENTS | DECIPHERA PHARMACEUTICALS, LLC (US) | 2008-05-15 | — | — | US | disclosed |
| US-20070078121-A1 | Enzyme modulators and treatments | DECIPHERA PHARMACEUTICALS, LLC | 2007-04-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070078121-A1 | Enzyme modulators and treatments | ABL1, ABL2, LCK | MAPK14 128/4885MAPK13 162/4885MAPK12 160/4885 |
| US-20080113967-A1 | ENZYME MODULATORS AND TREATMENTS | ABL2, BRAF, MAP3K1 | MAPK14 100/4885MAPK13 118/4885MAPK12 99/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.