Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 15/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 9/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 8/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 8/20 | 0.51 |
| ▸ | ABL1 | P00519 | 2/20 | 0.49 |
| ▸ | BRAF | P15056 | 2/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.44 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2081549 | 0.99 | MAPK14 (0.51) | MAPK14MAPK13MAPK12MAPK11ABL1 | |
| SCHEMBL2617025 | 0.92 | MAPK14 (0.52) | MAPK14MAPK13MAPK12MAPK11ABL1 | |
| SCHEMBL2083343 | 0.85 | ABL1 (0.69) | MAPK14MAPK11ABL1BRAF | |
| SCHEMBL2617024 | 0.85 | ABL1 (0.69) | MAPK14MAPK11ABL1BRAF | |
| SCHEMBL2083800 | 0.80 | ABL1 (0.67) | MAPK14MAPK13MAPK12MAPK11ABL1 | |
| SCHEMBL2084383 | 0.80 | ABL1 (0.59) | MAPK14MAPK13MAPK12MAPK11ABL1 | |
| SCHEMBL2083056 | 0.78 | MAPK14 (0.52) | MAPK14MAPK13MAPK12MAPK11ABL1 | |
| SCHEMBL2080268 | 0.74 | ABL1 (0.57) | MAPK14MAPK13MAPK12MAPK11ABL1 | |
| SCHEMBL2083128 | 0.74 | ABL1 (0.69) | MAPK14MAPK13MAPK12MAPK11ABL1 | |
| SCHEMBL2082454 | 0.74 | MAPK14 (0.52) | MAPK14MAPK13MAPK12MAPK11ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1835934-A2 | ENZYME MODULATORS AND TREATMENTS | Deciphera Pharmaceuticals, LLC (US) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006071940-A2 | ENZYME MODULATORS AND TREATMENTS | DECIPHERA PHARMACEUTICALS, LLC (US) | 2006-07-06 | — | — | WO | disclosed |