Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26494224 | 0.90 | HRH3 (0.55) | HRH3SMN1; SMN2ALDH1A1CYP2D6KCNH2 | |
| SCHEMBL14453911 | 0.85 | HRH3 (0.60) | HRH3SMN1; SMN2ALDH1A1CYP2D6KCNH2 | |
| SCHEMBL18704924 | 0.85 | HPGD (0.52) | HRH3SMN1; SMN2ALDH1A1HPGDTSHR | |
| SCHEMBL25480249 | 0.84 | HRH3 (0.56) | HRH3SMN1; SMN2ALDH1A1CYP2D6KCNH2 | |
| SCHEMBL25480250 | 0.84 | HRH3 (0.56) | HRH3SMN1; SMN2ALDH1A1CYP2D6KCNH2 | |
| SCHEMBL26170554 | 0.83 | HRH3 (0.46) | HRH3SMN1; SMN2ALDH1A1CYP2D6KCNH2 | |
| SCHEMBL14472575 | 0.82 | HTT (0.51) | HRH3ALDH1A1TSHRKMT2A | |
| SCHEMBL12384645 | 0.82 | NAMPT (0.43) | HRH3SMN1; SMN2ALDH1A1HPGDTSHR | |
| SCHEMBL26170628 | 0.81 | HSD11B1 (0.58) | HRH3SMN1; SMN2ALDH1A1HSD11B1MEN1 | |
| SCHEMBL26171347 | 0.81 | HRH3 (0.47) | HRH3SMN1; SMN2ALDH1A1CYP2D6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023098656-A1 | COMPOUNDS FOR THE DEGRADATION OF EGFR KINASE | BEIGENE, LTD. (GB) | 2023-06-08 | — | — | WO | disclosed |