Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | CREBBP | Q92793 | 5/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | EP300 | Q09472 | 1/20 | 0.50 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.50 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | GALR2 | O43603 | 1/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28567995 | 0.81 | KMT2A (0.46) | HTTKDM4EPOLBALDH1A1KMT2A | |
| SCHEMBL887130 | 0.79 | CREBBP (0.55) | HTTCREBBPKDM4EPOLBALDH1A1 | |
| SCHEMBL1333179 | 0.79 | HTT (0.54) | HTTCREBBPKDM4EPOLBALDH1A1 | |
| SCHEMBL887129 | 0.79 | HTT (0.54) | HTTCREBBPKDM4EPOLBALDH1A1 | |
| SCHEMBL28576106 | 0.79 | KMT2A (0.57) | KDM4EPOLBALDH1A1KMT2AMEN1 | |
| SCHEMBL4207590 | 0.78 | CREBBP (0.63) | HTTCREBBPKDM4EPOLBALDH1A1 | |
| SCHEMBL29037094 | 0.78 | NOTUM (0.62) | HTTCREBBPKDM4EPOLBALDH1A1 | |
| SCHEMBL13806317 | 0.78 | POLB (0.54) | HTTCREBBPKDM4EPOLBALDH1A1 | |
| SCHEMBL21062764 | 0.77 | P2RX4 (0.54) | POLBALDH1A1KMT2ANPSR1SMN1; SMN2 | |
| SCHEMBL30788389 | 0.77 | P2RX4 (0.54) | POLBALDH1A1KMT2ANPSR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11673901-B2 | Polycyclic compounds as allosteric SHP2 inhibitors | Revolution Medicines, Inc. (US) | 2023-06-13 | — | — | US | disclosed |
| CN-112574180-B | N-2-pyrimidinyl-3-fluoroindole compound and preparation method and application thereof | 浙江工业大学 | 2021-10-15 | — | — | CN | disclosed |
| CN-112574180-A | N-2-pyrimidinyl-3-fluoroindole compound and preparation method and application thereof | 浙江工业大学 | 2021-03-30 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11673901-B2 | Polycyclic compounds as allosteric SHP2 inhibitors | PTPN18, PTPN1, PTPRJ | HTT 943/4885CREBBP 768/4885KDM4E 979/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.