SCHEMBL26174983

SCHEMBL26174983

CN1CCN(C(=O)c2cnc3[nH]cc(-c4ccc5c(c4)C4(CCN(C)CC4)CC5=O)c3c2)CC1

nearest known ligand 0.53

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ MAP3K11 Q16584 7/20 0.53
▸ TNIK Q9UKE5 6/20 0.48
▸ ACACB O00763 1/20 0.43
▸ ACACA Q13085 1/20 0.43
▸ IGF1R P08069 2/20 0.43
▸ IL2 P60568 3/20 0.39
▸ MAP4K1 Q92918 3/20 0.39
▸ OTUD7B Q6GQQ9 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30399129 1.00 MAP3K11 (0.53) MAP3K11TNIKACACBACACAIGF1R
SCHEMBL26174982 0.94 MAP3K11 (0.51) MAP3K11TNIKACACBACACAIGF1R
SCHEMBL30400509 0.94 MAP3K11 (0.51) MAP3K11TNIKACACBACACAIGF1R
SCHEMBL26175064 0.87 MAP3K11 (0.43) MAP3K11TNIKACACBACACAIGF1R
SCHEMBL30400013 0.87 MAP3K11 (0.43) MAP3K11TNIKACACBACACAIGF1R
SCHEMBL30398693 0.87 MAP3K11 (0.40) MAP3K11TNIKACACBACACAIL2
SCHEMBL26175022 0.87 MAP3K11 (0.40) MAP3K11TNIKACACBACACAIL2
SCHEMBL30399632 0.85 EGLN1 (0.43) MAP3K11TNIKIL2MAP4K1
SCHEMBL26174944 0.85 EGLN1 (0.43) MAP3K11TNIKIL2MAP4K1
SCHEMBL26174759 0.85 MAP3K11 (0.44) MAP3K11TNIKIL2MAP4K1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230192686-A1 1H-PYRROLO[2,3-B]PYRIDINES AND PREPARATION AND USES THEREOF TENARX, INC. 2023-06-22 — — US disclosed
US-20230192686-A1 1H-PYRROLO[2,3-B]PYRIDINES AND PREPARATION AND USES THEREOF TENARX, INC. 2023-06-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230192686-A1 1H-PYRROLO[2,3-B]PYRIDINES AND PREPARATION AND USES THEREOF DYRK1A, DYRK1B, DYRK2 MAP3K11 72/4885TNIK 500/4885ACACB 2799/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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