Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.44 |
| ▸ | CLK1 | P49759 | 2/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.44 |
| ▸ | CLK2 | P49760 | 1/20 | 0.44 |
| ▸ | CLK3 | P49761 | 1/20 | 0.44 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 4/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 5/20 | 0.37 |
| ▸ | AKT1 | P31749 | 3/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | PLK1 | P53350 | 1/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26175940 | 0.88 | DYRK1A (0.58) | DYRK1ACDK5CLK1CDK5R1CLK2 | |
| SCHEMBL26175977 | 0.83 | DYRK1A (0.41) | DYRK1ACDK5CLK1CDK5R1CLK2 | |
| SCHEMBL26175737 | 0.82 | TGFBR1 (0.43) | DYRK1ACDK5CLK1CDK5R1CLK2 | |
| SCHEMBL26175678 | 0.79 | CYP2A6 (0.40) | DYRK1ACDK5CLK1CDK5R1CLK2 | |
| SCHEMBL26174486 | 0.79 | TGFBR1 (0.53) | DYRK1ACDK5CLK1CDK5R1CLK2 | |
| SCHEMBL26176055 | 0.79 | CYP2A6 (0.40) | DYRK1ACDK5CLK1CDK5R1CLK2 | |
| SCHEMBL25156900 | 0.76 | CYP2A6 (0.38) | DYRK1ACDK5CLK1CDK2GSK3B | |
| SCHEMBL30347862 | 0.76 | CYP2A6 (0.38) | DYRK1ACDK5CLK1CDK2GSK3B | |
| SCHEMBL26174734 | 0.76 | CLK1 (0.45) | DYRK1ACLK1CDK2CYP2A6PDPK1 | |
| SCHEMBL26175776 | 0.76 | DYRK1A (0.37) | DYRK1ACDK5CLK1CDK5R1CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230192686-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AND PREPARATION AND USES THEREOF | TENARX, INC. | 2023-06-22 | — | — | US | disclosed |
| US-20230192686-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AND PREPARATION AND USES THEREOF | TENARX, INC. | 2023-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230192686-A1 | 1H-PYRROLO[2,3-B]PYRIDINES AND PREPARATION AND USES THEREOF | DYRK1A, DYRK1B, DYRK2 | DYRK1A 1/4885CDK5 83/4885CLK1 268/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.