SCHEMBL26200092

SCHEMBL26200092

CC(C)CC(=O)Nc1nc2c(ncn2C(C)(C)C)c(=O)[nH]1

nearest known ligand 0.46

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.42
TSHR P16473 1/20 0.42
KMT2A Q03164 1/20 0.42
TAS1R3 Q7RTX0 1/20 0.37
TAS1R1 Q7RTX1 1/20 0.37
CDK5 Q00535 2/20 0.37
CDK5R1 Q15078 2/20 0.37
SMN1; SMN2 Q16637 3/20 0.37
KDM4E B2RXH2 2/20 0.37
ALDH1A1 P00352 2/20 0.37
HPGD P15428 1/20 0.37
GAA P10253 1/20 0.36
NPC1 O15118 1/20 0.35
RAB9A P51151 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18349588 0.85 KDM4E (0.46) MEN1TSHRKMT2ATAS1R3TAS1R1
SCHEMBL27444817 0.85 MEN1 (0.44) MEN1TSHRKMT2ATAS1R3TAS1R1
SCHEMBL21168954 0.84 CDK5 (0.52) MEN1TSHRKMT2ATAS1R3TAS1R1
SCHEMBL25964378 0.83 MEN1 (0.55) MEN1TSHRKMT2ATAS1R3TAS1R1
SCHEMBL26200096 0.80 NPC1 (0.51) MEN1TSHRKMT2ASMN1; SMN2KDM4E
SCHEMBL14725444 0.78 PI4KA (0.39) MEN1TSHRKMT2A
SCHEMBL24922819 0.76 PI4KA (0.38) MEN1TSHRKMT2A
SCHEMBL10047156 0.76 PI4KA (0.38) MEN1TSHRKMT2A
SCHEMBL26200392 0.75 MEN1 (0.42) MEN1TSHRKMT2ATAS1R3TAS1R1
SCHEMBL21654897 0.75 RAF1 (0.43) MEN1TSHRKMT2ASMN1; SMN2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230271998-A1 SOLID SUPPORT FOR SYNTHESIZING NUCLEIC ACID SEQUENCES AND METHODS FOR MAKING AND USING UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2023-08-31 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230271998-A1 SOLID SUPPORT FOR SYNTHESIZING NUCLEIC ACID SEQUENCES AND METHODS FOR MAKING AND USING RNGTT, NSUN2, POLN MEN1 625/4885TSHR 3625/4885KMT2A 971/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.