Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26035522 | 0.90 | KDM4E (0.45) | SCN9AKDM4ERXFP1MCHR1 | |
| SCHEMBL1018219 | 0.89 | ALB (0.49) | KDM4E | |
| SCHEMBL2619367 | 0.85 | F10 (0.45) | — | |
| SCHEMBL2620358 | 0.84 | F10 (0.47) | SCN9AKDM4E | |
| SCHEMBL2619786 | 0.84 | F10 (0.47) | SCN9ATRPV1 | |
| SCHEMBL12727142 | 0.84 | KDM4E (0.64) | KDM4ERXFP1 | |
| SCHEMBL12214705 | 0.84 | F10 (0.46) | — | |
| SCHEMBL12727146 | 0.83 | SCN9A (0.49) | SCN9AKDM4E | |
| SCHEMBL12215504 | 0.79 | KCNK3 (0.50) | TRPV1 | |
| SCHEMBL10287501 | 0.78 | TRPV1 (0.46) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120094980-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GUNZNER JANET L (US) | 2012-04-19 | — | — | US | disclosed |
| US-20110092461-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | CURIS ROYALTY LLC | 2011-04-21 | — | — | US | disclosed |
| US-20090281089-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281089-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | SHH, GLI1, SMO | SCN9A 4128/4885KDM4E 411/4885RXFP1 62/4885 |
| US-20120094980-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | SHH, GLI1, SMO | SCN9A 4128/4885KDM4E 411/4885RXFP1 62/4885 |
| US-20110092461-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | SHH, GLI1, SMO | SCN9A 4128/4885KDM4E 411/4885RXFP1 62/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.