Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 1/20 | 0.47 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.45 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2619367 | 0.91 | F10 (0.45) | F10CREBBP | |
| SCHEMBL12214705 | 0.90 | F10 (0.46) | F10CREBBP | |
| SCHEMBL26038393 | 0.90 | CSF1R (0.47) | F10CREBBPCSF1RKITKDR | |
| SCHEMBL2620358 | 0.89 | F10 (0.47) | F10SCN9A | |
| SCHEMBL1019134 | 0.89 | ALB (0.51) | F10CREBBPKDR | |
| SCHEMBL2620360 | 0.84 | SCN9A (0.46) | SCN9ATRPV1 | |
| SCHEMBL2619308 | 0.84 | BTK (0.57) | CSF1RKITRAB9AKDR | |
| SCHEMBL12727156 | 0.82 | RAB9A (0.54) | SCN9ARAB9A | |
| SCHEMBL26035569 | 0.82 | CREBBP (0.47) | CREBBPNPC1RAB9ATRPV1 | |
| SCHEMBL26035597 | 0.81 | MAPK14 (0.46) | CREBBPNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120094980-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GUNZNER JANET L (US) | 2012-04-19 | — | — | US | disclosed |
| US-8030454-B2 | Anti-hedgehog antibodies | GENENTECH, INC. (US) | 2011-10-04 | — | — | US | disclosed |
| US-20110092461-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | CURIS ROYALTY LLC | 2011-04-21 | — | — | US | disclosed |
| US-20100003239-A1 | ANTI-HEDGEHOG ANTIBODIES | GENENTECH, INC. (US) | 2010-01-07 | — | — | US | disclosed |
| US-20090281089-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | GENENTECH, INC. (US) | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100003239-A1 | ANTI-HEDGEHOG ANTIBODIES | SHH, SMO, GLI1 | F10 3366/4885CREBBP 841/4885CSF1R 632/4885 |
| US-20090281089-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | SHH, GLI1, SMO | F10 2724/4885CREBBP 978/4885CSF1R 256/4885 |
| US-20120094980-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | SHH, GLI1, SMO | F10 2724/4885CREBBP 978/4885CSF1R 256/4885 |
| US-20110092461-A1 | PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING | SHH, GLI1, SMO | F10 2724/4885CREBBP 978/4885CSF1R 256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.