Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | PI4KA | P42356 | 1/20 | 0.43 |
| ▸ | XDH | P47989 | 1/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.43 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.43 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | DHFR | P00374 | 3/20 | 0.33 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.33 |
| ▸ | DLK1 | P80370 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25920026 | 0.81 | RET (0.43) | RETPI4KAXDHLRRK2PI4K2B | |
| SCHEMBL25898919 | 0.76 | RET (0.47) | RETPI4KAXDHLRRK2PI4K2B | |
| SCHEMBL1482228 | 0.73 | RET (0.44) | RETPI4KAXDHLRRK2PI4K2B | |
| SCHEMBL21579421 | 0.72 | RET (0.47) | RETPI4KAXDHLRRK2PI4K2B | |
| SCHEMBL30515856 | 0.72 | RET (0.47) | RETPI4KAXDHLRRK2PI4K2B | |
| SCHEMBL21579418 | 0.72 | RET (0.47) | RETPI4KAXDHLRRK2PI4K2B | |
| SCHEMBL30515967 | 0.72 | RET (0.47) | RETPI4KAXDHLRRK2PI4K2B | |
| SCHEMBL20176891 | 0.71 | KDM4E (0.45) | RETPI4KAXDHLRRK2PI4K2B | |
| SCHEMBL25908871 | 0.71 | RET (0.43) | RETPI4KAXDHLRRK2PI4K2B | |
| SCHEMBL15629902 | 0.71 | MAPT (0.36) | RETPI4KAXDHLRRK2PI4K2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023146987-A1 | COMPOUNDS AND METHODS OF USE | TANGO THERAPEUTICS, INC. (US) | 2023-08-03 | — | — | WO | disclosed |