Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL261310 | 0.92 | MEN1 (0.44) | MEN1KMT2AGAAALOX15KDM4E | |
| SCHEMBL14248432 | 0.83 | MEN1 (0.48) | MEN1KMT2AGAAALOX15KDM4E | |
| SCHEMBL14248142 | 0.83 | MEN1 (0.49) | MEN1KMT2AGAAALOX15KDM4E | |
| SCHEMBL14248140 | 0.83 | MEN1 (0.49) | MEN1KMT2AGAAALOX15KDM4E | |
| SCHEMBL14248570 | 0.82 | MEN1 (0.51) | MEN1KMT2AGAAALOX15KDM4E | |
| SCHEMBL261426 | 0.81 | MEN1 (0.44) | MEN1KMT2AGAAALOX15DHODH | |
| SCHEMBL14248150 | 0.81 | MEN1 (0.48) | MEN1KMT2AGAAKDM4EPIK3CD | |
| SCHEMBL261692 | 0.81 | MEN1 (0.48) | MEN1KMT2AGAAKDM4EPIK3CD | |
| SCHEMBL14248443 | 0.79 | MEN1 (0.48) | MEN1KMT2AGAAKDM4EPIK3CD | |
| SCHEMBL14247997 | 0.79 | MEN1 (0.49) | MEN1KMT2AGAAALOX15KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133882-B2 | Quinolone derivative or pharmaceutically acceptable salt thereof | ASTELLAS PHARMA INC (JP) | 2012-03-13 | — | — | US | disclosed |
| EP-1995240-B1 | QUINOLONE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | ASTELLAS PHARMA INC (JP) | 2012-02-22 | — | — | EP | disclosed |