Miltefosine

Miltefosine

SCHEMBL26215

CCCCCCCCCCCCCCCCOP(=O)([O-])OCC[N+](C)(C)C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 1.00
AKT1 P31749 2/20 1.00
ESR1 P03372 1/20 1.00
ADORA3 P0DMS8 1/20 1.00
CDC25A P30304 1/20 1.00
AGTR1 P30556 1/20 1.00
ADRA1A P35348 1/20 1.00
KCNH2 Q12809 1/20 1.00
SMN1; SMN2 Q16637 2/20 0.69
PRKD3 O94806 1/20 0.69
PRKCG P05129 1/20 0.69
PRKCB P05771 1/20 0.69
PRKCA P17252 1/20 0.69
PRKCH P24723 1/20 0.69
PRKCI P41743 1/20 0.69
PRKCE Q02156 1/20 0.69
PRKCQ Q04759 1/20 0.69
PRKCZ Q05513 1/20 0.69
PRKCD Q05655 1/20 0.69
PRKD1 Q15139 1/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10415264 1.00 LMNA (1.00) LMNAAKT1ESR1ADORA3CDC25A
Miltefosine SCHEMBL20769827 1.00 LMNA (1.00) LMNAAKT1ESR1ADORA3CDC25A
SCHEMBL4166195 1.00 LMNA (1.00) LMNAAKT1ESR1ADORA3CDC25A
SCHEMBL596694 1.00 LMNA (1.00) LMNAAKT1ESR1ADORA3CDC25A
Octadecylphosphonocholine SCHEMBL744376 1.00 LMNA (1.00) LMNAAKT1ESR1ADORA3CDC25A
Tetradecylphosphocholine SCHEMBL5481590 1.00 LMNA (1.00) LMNAAKT1ESR1ADORA3CDC25A
SCHEMBL29465558 1.00 LMNA (1.00) LMNAAKT1ESR1ADORA3CDC25A
Miltefosine SCHEMBL7189058 0.98 LMNA (0.97) LMNAAKT1ESR1ADORA3CDC25A
SCHEMBL9234856 0.98 LMNA (0.96) LMNAAKT1ESR1ADORA3CDC25A
SCHEMBL10934123 0.94 LMNA (0.88) LMNAAKT1ESR1ADORA3CDC25A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 25537 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117180287-B Application of miltefosine in promoting bone formation and preventing and treating osteoporosis 浙江省中医院、浙江中医药大学附属第一医院(浙江省东方医院) 2026-05-19 CN claimed
EP-4255391-B1 LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION METRIOPHARM AG (CH) 2026-05-06 EP claimed
US-20260116861-A1 ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONALLY CHARTERED NOT-FOR-PROFIT CORPORATION (US) 2026-04-30 US claimed
EP-4732908-A2 CANCER TREATMENT USING COMBINATIONS OF ERK AND RAF INHIBITORS Biomed Valley Discoveries, Inc. (US) 2026-04-29 EP claimed
US-20260108619-A1 CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS HANGZHOU DAC BIOTECH CO., LTD. (CN) 2026-04-23 US claimed
EP-4363043-B1 COMPOSITIONS FOR USE IN METHODS FOR INCREASING CANCER CELL SENSITIVITY TO ALTERNATING ELECTRIC FIELDS NOVOCURE GMBH (CH) 2026-04-22 EP claimed
US-20260097028-A1 Methods of Treating Myeloproliferative Neoplasms KARTOS THERAPEUTICS INC (US) 2026-04-09 US claimed
US-12594421-B2 Compositions and methods for increasing cancer cell sensitivity to alternating electric fields NOVOCURE GMBH (CH) 2026-04-07 US claimed
EP-4710927-A1 OLEYLPHOSPHOCHOLINE IN THE TREATMENT OF LEISHMANIASIS Oblita Therapeutics BVBA (BE) 2026-03-18 EP claimed
US-12576124-B2 Formulation of a conjugate of a tubulysin analog to a cell-binding molecule HANGZHOU DAC BIOTECH CO., LTD (CN) 2026-03-17 US claimed
WO-1996014871-A1 IMMUNOGENIC COMPOSITIONS CORTECS LIMITED (GB) 1996-05-23 WO claimed
US-5446033-A Antitumor agent; storage stability, antiseptic, chemical resistance, by-product inhibition ASTA MEDICA AG (DE) 1995-08-29 US claimed
WO-1995013795-A1 HYDROPHOBIC PREPARATIONS CORTECS LIMITED (GB) 1995-05-26 WO claimed
EP-0393575-B1 Neoplasia treatment compositions containing antineoplastic agent and side-effect reducing protective agent SEARLE & CO (US) 1994-03-16 EP claimed
US-5290769-A Applying compositions for skin disorders ASTA PHARMA AKTIENGESELLSCHAFT (DE) 1994-03-01 US claimed
EP-0359981-B1 PHARMACEUTICAL COMBINATIONS AND THEIR USE AS ANTINEOPLASTIC MEDICINES Roche Diagnostics GmbH (DE) 1993-07-28 EP claimed
US-5049552-A Anticancer agents MAX-PLANCK-GESELLSCHAFT FUR FOERDERUNG DER WISSENSCHAFTEN E.V. (DE) 1991-09-17 US claimed
EP-0248047-B1 MEDICAMENT WITH ANTI-TUMORAL ACTION CONTAINING HEXADECYLPHOSPHOCHOLINE Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 1991-06-19 EP claimed
EP-0393575-A1 Neoplasia treatment compositions containing antineoplastic agent and side-effect reducing protective agent G.D. Searle & Co. (US) 1990-10-24 EP claimed
US-4837023-A ANTICARCINOGENIC AGENTS, ANTITUMOR AGENTS MAX-PLANCK-GESELLSCHAFT ZUR FOEDERUNG DER WISSENSCHAFTEN (DE) 1989-06-06 US claimed