Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspirin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 5/20 | 0.67 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.67 |
| ▸ | HPGD | P15428 | 4/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | ESR1 | P03372 | 1/20 | 0.67 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.67 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.67 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | GGT1 | P19440 | 1/20 | 0.67 |
| ▸ | BLM | P54132 | 1/20 | 0.67 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspirin SCHEMBL11598010 | 0.98 | KDM4E (0.65) | KDM4EPTGS2HSD17B10HPGDALDH1A1 | |
| Aspirin SCHEMBL11343895 | 0.98 | KDM4E (0.65) | KDM4EPTGS2HSD17B10HPGDALDH1A1 | |
| Aspirin SCHEMBL28860661 | 0.96 | KDM4E (0.68) | KDM4EPTGS2HSD17B10HPGDALDH1A1 | |
| Aspirin SCHEMBL1939134 | 0.96 | KDM4E (0.67) | KDM4EPTGS2HSD17B10HPGDALDH1A1 | |
| Aspirin SCHEMBL24830 | 0.96 | KDM4E (0.67) | KDM4EPTGS2HSD17B10HPGDALDH1A1 | |
| Aspirin SCHEMBL162391 | 0.96 | KDM4E (0.67) | KDM4EPTGS2HSD17B10HPGDALDH1A1 | |
| Aspirin SCHEMBL191054 | 0.96 | KDM4E (0.67) | KDM4EPTGS2HSD17B10HPGDALDH1A1 | |
| Aspirin SCHEMBL4534925 | 0.96 | KDM4E (0.67) | KDM4EPTGS2HSD17B10HPGDALDH1A1 | |
| Aspirin SCHEMBL7250097 | 0.96 | KDM4E (0.67) | KDM4EPTGS2HSD17B10HPGDALDH1A1 | |
| Aspirin SCHEMBL21328428 | 0.96 | KDM4E (0.67) | KDM4EPTGS2HSD17B10HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2128 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-224269602-U | Knapsack is searched to wounded person | Institute of Medical Support Technology of Academy of System Engineering of Academy of Military Science (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-118853815-A | Wheat scab fungus field development progress observation box and early warning method | 河南省农业科学院植物保护研究所 | 2024-10-29 | — | — | CN | claimed |
| CN-221853223-U | Flexible security inspection channel | 北京金法保安服务有限公司 | 2024-10-18 | — | — | CN | claimed |
| CN-118662754-A | Intermediate catheter assembly and conveying system | 北京久事神康医疗科技有限公司 | 2024-09-20 | — | — | CN | claimed |
| EP-3457848-B1 | AGROCHEMICAL COMBINATION | CROP INTELLECT LTD (GB) | 2024-08-07 | — | — | EP | claimed |
| CN-113793377-B | Method for investigating quantity of fusarium graminearum ascomycetes on field straw stubble | 河南省农业科学院植物保护研究所 | 2024-04-26 | — | — | CN | claimed |
| US-20240041935-A1 | PREVENTION AND TREATMENT OF REPRODUCTIVE FAILURE BY REGENERATIVE CELLS AND ADJUVANTS | CREATIVE MEDICAL TECHNOLOGIES, INC. (US) | 2024-02-08 | — | — | US | claimed |
| CN-116568140-A | Use of microorganisms and calcium for improving plant health and/or restoring force against plant pathogens | 维也纳农业大学 | 2023-08-08 | — | — | CN | claimed |
| CN-116326398-A | Sclerotinia sclerotiorum prediction model based on surface soil humidity and ascofacial development | 中国农业大学 | 2023-06-27 | — | — | CN | claimed |
| US-20220211621-A1 | LIPOSOMAL SUSTAINED-RELEASE COMPOSITIONS CONTAINING A THERAPEUTIC DRUG AND USE THEREOF | TLC BIOPHARMACEUTICALS, INC. | 2022-07-07 | — | — | US | claimed |
| EP-0792371-A1 | COMBINATION METHOD FOR ACNE TREATMENT | Merck & Co., Inc. (US) | 1997-09-03 | — | — | EP | claimed |
| EP-0759750-A1 | COMPOSITIONS FOR TREATMENT OF CHRONIC INFLAMMATORY DISEASES | SHAPIRO, Howard, K. (US) | 1997-03-05 | — | — | EP | claimed |
| US-5543417-A | 5 Alpha-reductase inhibitor and at least one of an antibacterial agent, a keratolytic agent or an anti-inflammatory agent | MERCK & CO., INC. (US) | 1996-08-06 | — | — | US | claimed |
| WO-1996012817-A1 | COMBINATION METHOD FOR ACNE TREATMENT | MERCK & CO., INC. (US) | 1996-05-02 | — | — | WO | claimed |
| WO-1995031194-A1 | COMPOSITIONS FOR TREATMENT OF CHRONIC INFLAMMATORY DISEASES | SHAPIRO HOWARD K (US) | 1995-11-23 | — | — | WO | claimed |
| WO-1990003997-A1 | EFFECT OF USING CHEMICAL MODIFIERS IN THE CURING OF POLYURETHANE FOAMS | PACIFIC DUNLOP LIMITED (AU) | 1990-04-19 | — | — | WO | claimed |
| EP-0024690-B1 | ANALGESIC MIXTURE OF NALBUPHINE AND ACETYLSALICYLIC ACID, DERIVATIVE OR SALT THEREOF | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1983-07-20 | — | — | EP | claimed |
| US-4282215-A | Analgesic mixture of nalbuphine and acetylsalicylic acid, derivative or salt thereof | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-08-04 | — | — | US | claimed |
| EP-0024690-A1 | Analgesic mixture of nalbuphine and acetylsalicylic acid, derivative or salt thereof | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1981-03-11 | — | — | EP | claimed |
| US-4117603-A | High vacuum freeze-drying | SMITH WALTON J | 1978-10-03 | — | — | US | claimed |