Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Aspirin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 5/20 | 0.67 |
| ▸ | PTGS1 known ✓ | P23219 | 1/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.67 |
| ▸ | HPGD | P15428 | 4/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | ESR1 | P03372 | 1/20 | 0.67 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.67 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.67 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.67 |
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | GGT1 | P19440 | 1/20 | 0.67 |
| ▸ | BLM | P54132 | 1/20 | 0.67 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aspirin SCHEMBL26228 | 0.96 | KDM4E (0.67) | KDM4EPTGS2HSD17B10HPGDALDH1A1 | |
| Aspirin SCHEMBL1939134 | 0.96 | KDM4E (0.67) | KDM4EPTGS2HSD17B10HPGDALDH1A1 | |
| Aspirin SCHEMBL1457620 | 0.96 | KDM4E (0.67) | KDM4EPTGS2HSD17B10HPGDALDH1A1 | |
| Aspirin SCHEMBL191054 | 0.96 | KDM4E (0.67) | KDM4EPTGS2HSD17B10HPGDALDH1A1 | |
| Aspirin SCHEMBL21328428 | 0.96 | KDM4E (0.67) | KDM4EPTGS2HSD17B10HPGDALDH1A1 | |
| Aspirin SCHEMBL24830 | 0.96 | KDM4E (0.67) | KDM4EPTGS2HSD17B10HPGDALDH1A1 | |
| Aspirin SCHEMBL3677210 | 0.96 | KDM4E (0.67) | KDM4EPTGS2HSD17B10HPGDALDH1A1 | |
| Aspirin SCHEMBL4534925 | 0.96 | KDM4E (0.67) | KDM4EPTGS2HSD17B10HPGDALDH1A1 | |
| Aspirin SCHEMBL162391 | 0.96 | KDM4E (0.67) | KDM4EPTGS2HSD17B10HPGDALDH1A1 | |
| Aspirin SCHEMBL2157062 | 0.96 | KDM4E (0.67) | KDM4EPTGS2HSD17B10HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6632577-B2 | Toner of a colorant, a methylene chain containing release agent, and a binder with a peak in the region of a molecular weight of from 2,000-50,000 and at least a peak or a shoulder in 100,000 | CANON KABUSHIKI KAISHA (JP) | 2003-10-14 | — | — | US | disclosed |
| US-20020106575-A1 | IMAGE FORMING METHOD | AKASHI YASUTAKA (JP) | 2002-08-08 | — | — | US | disclosed |
| US-6342328-B1 | BINDER RESIN, COLOR AND CHARGE CONTROL AGENT | NIPPON ZEON CO., LTD. (JP) | 2002-01-29 | — | — | US | disclosed |
| US-4626489-A | Process for producing toner for development of electrostatic images by stepwise suspension polymerization | CANON KABUSHIKI KAISHA (JP) | 1986-12-02 | — | — | US | disclosed |
| US-4609607-A | Magnetic toner and process for producing the same | CANON KABUSHIKI KAISHA (JP) | 1986-09-02 | — | — | US | disclosed |
| US-4601968-A | Process for producing toner for development of electrostatic images by stepwise suspension polymerizations | CANON KABUSHIKI KAISHA (JP) | 1986-07-22 | — | — | US | disclosed |