Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 3/20 | 0.39 |
| ▸ | AKR1A1 | P14550 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 2/20 | 0.37 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 3/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26232349 | 0.76 | AKR1B1 (0.58) | AKR1B1AKR1A1KDM1AADAMTS5SLC6A9 | |
| SCHEMBL21844215 | 0.74 | AKR1B1 (0.62) | AKR1B1AKR1A1 | |
| SCHEMBL29878889 | 0.71 | HTR2C (0.47) | KDM1AALDH1A1 | |
| SCHEMBL1515236 | 0.71 | HTR2C (0.47) | KDM1AALDH1A1 | |
| SCHEMBL10970570 | 0.68 | BACE1 (0.43) | AKR1B1OPRM1ALDH1A1POLBMAPT | |
| SCHEMBL21844225 | 0.67 | AKR1B1 (0.57) | AKR1B1AKR1A1 | |
| SCHEMBL730107 | 0.66 | ESR2 (0.47) | KDM4E | |
| SCHEMBL27794457 | 0.66 | HCRTR2 (0.44) | — | |
| Formamide SCHEMBL28182476 | 0.66 | PARP10 (0.44) | KDM1A | |
| SCHEMBL777204 | 0.64 | HDAC4 (0.52) | KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219905-A1 | ALDOKETO REDUCTASE INHIBITORS AND USES THEREOF | UNIV CASE WESTERN RESERVE (US) | 2023-07-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230219905-A1 | ALDOKETO REDUCTASE INHIBITORS AND USES THEREOF | AKR1B1, AKR1A1, AKR1C2 | AKR1B1 1/4885AKR1A1 2/4885KDM1A 1428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.