Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 9/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26240373 | 0.85 | MET (0.35) | MEN1KMT2AMETMAPTTP53 | |
| SCHEMBL26998998 | 0.85 | CYP1A2 (0.39) | MEN1KMT2ATRPV3METMAPT | |
| SCHEMBL29569742 | 0.84 | MEN1 (0.41) | MEN1KMT2AMETMAPTTP53 | |
| SCHEMBL23558978 | 0.84 | MEN1 (0.41) | MEN1KMT2AMETMAPTTP53 | |
| SCHEMBL23528790 | 0.83 | MAPT (0.39) | MEN1KMT2AMETMAPTTP53 | |
| SCHEMBL29569518 | 0.83 | CYP1A2 (0.40) | MEN1KMT2ATRPV3METMAPT | |
| SCHEMBL23558984 | 0.83 | CYP1A2 (0.40) | MEN1KMT2ATRPV3METMAPT | |
| SCHEMBL23528550 | 0.82 | CYP11B1 (0.43) | MEN1KMT2AMETMAPTTP53 | |
| SCHEMBL29569470 | 0.82 | CYP11B1 (0.43) | MEN1KMT2AMETMAPTTP53 | |
| SCHEMBL26999000 | 0.82 | MAPT (0.39) | MEN1KMT2AMETMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4248973-A2 | PYRIDAZINONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2023-09-27 | — | — | EP | disclosed |
| EP-3877376-B1 | PYRIDAZINONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS INC (US) | 2023-08-23 | — | — | EP | disclosed |