Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 16/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27000186 | 0.82 | MET (0.40) | METHDAC1TP53 | |
| SCHEMBL23528315 | 0.82 | MET (0.40) | METTP53 | |
| SCHEMBL23528371 | 0.79 | MET (0.41) | METTP53 | |
| SCHEMBL23528527 | 0.78 | MET (0.41) | METTP53 | |
| SCHEMBL23528302 | 0.77 | MET (0.51) | METTP53 | |
| SCHEMBL26234319 | 0.76 | MET (0.39) | METTP53 | |
| SCHEMBL29570613 | 0.76 | MET (0.37) | METTP53 | |
| SCHEMBL29569447 | 0.76 | MET (0.37) | METTP53 | |
| SCHEMBL23528294 | 0.76 | MET (0.37) | METTP53 | |
| SCHEMBL29569719 | 0.76 | MET (0.37) | METTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4248973-A2 | PYRIDAZINONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS, INC. (US) | 2023-09-27 | — | — | EP | disclosed |
| EP-3877376-B1 | PYRIDAZINONE COMPOUNDS AND USES THEREOF | EDGEWISE THERAPEUTICS INC (US) | 2023-08-23 | — | — | EP | disclosed |