Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 2/20 | 0.39 |
| ▸ | AKT1 | P31749 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 2/20 | 0.35 |
| ▸ | PIM1 | P11309 | 2/20 | 0.35 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.34 |
| ▸ | GRM8 | O00222 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22296030 | 0.76 | BLM (0.37) | KCNH2GPR35LRRK2ROCK1 | |
| SCHEMBL21193333 | 0.71 | KCNH2 (0.41) | KCNH2KDM4EALDH1A1AKT2AKT1 | |
| SCHEMBL13160337 | 0.70 | KDM4E (0.38) | KCNH2KDM4EALDH1A1AKT2AKT1 | |
| SCHEMBL12668067 | 0.68 | KDM4E (0.41) | KDM4EALDH1A1LMNA | |
| SCHEMBL3740850 | 0.68 | AKT2 (0.70) | KCNH2AKT2AKT1LMNAAPEX1 | |
| SCHEMBL19003127 | 0.68 | KCNH2 (0.43) | KCNH2KDM4EALDH1A1AKT2AKT1 | |
| SCHEMBL29518143 | 0.68 | KCNH2 (0.43) | KCNH2KDM4EALDH1A1AKT2AKT1 | |
| SCHEMBL15716268 | 0.68 | MTOR (0.38) | KCNH2KDM4EALDH1A1AKT2AKT1 | |
| SCHEMBL21193154 | 0.68 | KDM4E (0.42) | KCNH2KDM4EALDH1A1AKT2AKT1 | |
| SCHEMBL26242537 | 0.67 | MAPT (0.43) | KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023150201-A2 | SODIUM CHANNEL BLOCKING COMPOUNDS, DERIVATIVES THEREOF, AND METHODS OF THEIR USE | LATIGO BIOTHERAPEUTICS, INC. (US) | 2023-08-10 | — | — | WO | disclosed |