Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.39 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.38 |
| ▸ | SMO | Q99835 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.35 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.35 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26242505 | 0.82 | MAOB (0.44) | MAPTSMN1; SMN2MAPK14PKMCSNK1A1 | |
| SCHEMBL26242506 | 0.82 | CNR1 (0.45) | MAPTLMNASMN1; SMN2NOTUMKDM4E | |
| SCHEMBL26242512 | 0.78 | ADORA2A (0.44) | MAPK14MAPK11CSNK1DMAPK13MAPK12 | |
| SCHEMBL15038342 | 0.78 | LMNA (0.40) | MAPTLMNASMN1; SMN2MAPK14MAPK11 | |
| SCHEMBL26242535 | 0.78 | CYP2A6 (0.53) | MAPTLMNASMN1; SMN2TP53HPGD | |
| Ammonia Solution, Strong SCHEMBL17728179 | 0.78 | SMN1; SMN2 (0.47) | SMN1; SMN2MAPK14MAPK11CSNK1DMAPK13 | |
| SCHEMBL4092576 | 0.75 | SMN1; SMN2 (0.49) | MAPTLMNASMN1; SMN2MAPK14MAPK11 | |
| SCHEMBL26246652 | 0.75 | KMT2A (0.54) | MAPTLMNATP53HPGDGAA | |
| SCHEMBL12668067 | 0.74 | KDM4E (0.41) | LMNAKDM4EALDH1A1ALOX15HSD17B10 | |
| SCHEMBL26242510 | 0.74 | SMO (0.34) | SMONOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023150201-A2 | SODIUM CHANNEL BLOCKING COMPOUNDS, DERIVATIVES THEREOF, AND METHODS OF THEIR USE | LATIGO BIOTHERAPEUTICS, INC. (US) | 2023-08-10 | — | — | WO | disclosed |
| CN-1251097-B | Phthalazines with angiogenesis inhibiting activity | NOVARTIS AG | 2011-10-19 | — | — | CN | disclosed |
| CN-1251097-A | Phthalazines with angiogenesis inhibiting activity | NOVARTIS AG (CH) | 2000-04-19 | — | — | CN | disclosed |