Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 4/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20846484 | 0.90 | HPGD (0.43) | HPGDSMN1; SMN2MEN1KMT2AGAA | |
| SCHEMBL26003807 | 0.81 | KDM4E (0.46) | ACHEMEN1KMT2ACYP2C19 | |
| SCHEMBL1847673 | 0.81 | DPP4 (0.32) | — | |
| SCHEMBL3780842 | 0.81 | DPP4 (0.32) | — | |
| SCHEMBL3779703 | 0.77 | RECQL (0.31) | — | |
| SCHEMBL13840397 | 0.76 | HPGD (0.41) | ACHEHPGDSMN1; SMN2MEN1KMT2A | |
| SCHEMBL8698034 | 0.75 | SIGMAR1 (0.31) | SIGMAR1MEN1KMT2A | |
| SCHEMBL3771733 | 0.73 | HPGD (0.31) | HPGDSMN1; SMN2CYP3A4CYP2C19 | |
| SCHEMBL23373370 | 0.72 | KMT2A (0.41) | HPGDSMN1; SMN2KMT2ATSHRGAA | |
| SCHEMBL20195364 | 0.71 | KCNH2 (0.35) | SIGMAR1HPGDTSHRGAACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3262036-B1 | THERAPEUTIC PYRIDAZINE COMPOUNDS AND USES THEREOF | GENENTECH INC (US) | 2023-09-13 | — | — | EP | disclosed |