SCHEMBL2624865

SCHEMBL2624865

CCc1cc(N2Cc3c(cc(O)c4c3OC(C)(CC/C=C(\C)CCC=C(C)C)C(O)C4)C2=O)ccc1C(=O)O

nearest known ligand 0.33

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ ALOX5 P09917 4/20 0.33
▸ PTPN1 P18031 1/20 0.33
▸ APP P05067 1/20 0.33
▸ PTGS2 P35354 4/20 0.33
▸ NR1H4 Q96RI1 2/20 0.32
▸ BACE1 P56817 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29725725 0.94 PTGS2 (0.35) ALOX5PTPN1APPPTGS2NR1H4
SCHEMBL2624837 0.94 PTGS2 (0.35) ALOX5PTPN1APPPTGS2NR1H4
SCHEMBL2624828 0.94 PTGS2 (0.35) ALOX5PTPN1APPPTGS2NR1H4
SCHEMBL2624863 0.92 PTGS2 (0.34) ALOX5PTPN1APPPTGS2NR1H4
SCHEMBL2624874 0.92 PTGS2 (0.34) ALOX5PTPN1APPPTGS2NR1H4
SCHEMBL29725717 0.89 BACE1 (0.36) ALOX5PTPN1APPPTGS2NR1H4
SCHEMBL2624870 0.89 BACE1 (0.36) ALOX5PTPN1APPPTGS2NR1H4
SCHEMBL2624871 0.89 BACE1 (0.36) ALOX5PTPN1APPPTGS2NR1H4
SCHEMBL2624817 0.88 BACE1 (0.34) ALOX5PTPN1APPPTGS2NR1H4
SCHEMBL2624835 0.88 BACE1 (0.34) ALOX5PTPN1APPPTGS2NR1H4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8883462-B2 Triprenyl phenol compound, process for production of triprenyl phenol compound, and thrombolysis enhancer TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY TLO CO., LTD. (JP) 2014-11-11 — — US disclosed
US-8883462-B2 Triprenyl phenol compound, process for production of triprenyl phenol compound, and thrombolysis enhancer TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY TLO CO., LTD. (JP) 2014-11-11 — — US disclosed
US-20120100579-A1 TRIPRENYL PHENOL COMPOUND, PROCESS FOR PRODUCTION OF TRIPRENYL PHENOL COMPOUND, AND THROMBOLYSIS ENHANCER TOKYO UNIVERSITY OF AGRICLATURE AND TECHNOLOGY TLO CO., LTD. (JP) 2012-04-26 — — US disclosed
US-20120100579-A1 TRIPRENYL PHENOL COMPOUND, PROCESS FOR PRODUCTION OF TRIPRENYL PHENOL COMPOUND, AND THROMBOLYSIS ENHANCER TOKYO UNIVERSITY OF AGRICLATURE AND TECHNOLOGY TLO CO., LTD. (JP) 2012-04-26 — — US disclosed
US-8110596-B2 Triprenyl phenol compound, process for production of triprenyl phenol compound, and thrombolysis enhancer TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY TLO CO., LTD. (JP) 2012-02-07 — — US disclosed
US-8110596-B2 Triprenyl phenol compound, process for production of triprenyl phenol compound, and thrombolysis enhancer TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY TLO CO., LTD. (JP) 2012-02-07 — — US disclosed
US-20090216028-A1 Triprenyl phenol compound, process for production of triprenyl phenol compound, and thrombolysis enhancer TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY TLO CO., LTD. (JP) 2009-08-27 — — US disclosed
US-20090216028-A1 Triprenyl phenol compound, process for production of triprenyl phenol compound, and thrombolysis enhancer TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY TLO CO., LTD. (JP) 2009-08-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090216028-A1 Triprenyl phenol compound, process for production of triprenyl phenol compound, and thrombolysis enhancer PLAT, F2R, F12 ALOX5 833/4885PTPN1 2463/4885APP 1517/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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