Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.33 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8368738 | 0.77 | — | — | |
| SCHEMBL20848461 | 0.64 | TSHR (0.42) | KDM4EALDH1A1CSNK2A2CSNK2BCSNK2A1 | |
| SCHEMBL9980116 | 0.63 | ATM (0.33) | ATM | |
| SCHEMBL6767648 | 0.63 | ATM (0.36) | ATM | |
| SCHEMBL10105029 | 0.61 | GRIA1 (0.42) | KDM4EALDH1A1ATM | |
| SCHEMBL22743552 | 0.60 | DAO (0.34) | ATM | |
| SCHEMBL16131591 | 0.60 | GRIA1 (0.41) | ATM | |
| SCHEMBL7762067 | 0.60 | ATM (0.37) | ATM | |
| SCHEMBL15563493 | 0.60 | DAO (0.38) | ATM | |
| SCHEMBL12702610 | 0.60 | DAO (0.38) | ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163763-B2 | Pyrimidine compounds, compositions and methods of use | GENENTECH, INC. (US) | 2012-04-24 | — | — | US | disclosed |
| US-8163763-B2 | Pyrimidine compounds, compositions and methods of use | GENENTECH, INC. (US) | 2012-04-24 | — | — | US | disclosed |