Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | AHCY | P23526 | 4/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.50 |
| ▸ | PDE2A | O00408 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
| ▸ | CA5A | P35218 | 1/20 | 0.48 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.44 |
| ▸ | DNMT3B | Q9UBC3 | 1/20 | 0.44 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.42 |
| ▸ | CD99 | P14209 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13146083 | 1.00 | NT5E (0.57) | NT5ELMNAHIF1AAHCYADORA2A | |
| SCHEMBL13146058 | 0.91 | ADORA2A (0.49) | NT5ELMNAHIF1AAHCYADORA2A | |
| SCHEMBL30689525 | 0.90 | NT5E (0.61) | NT5ELMNAHIF1AAHCYADORA2A | |
| SCHEMBL749004 | 0.90 | ADORA3 (0.50) | NT5ELMNAHIF1AAHCYADORA2A | |
| SCHEMBL13146049 | 0.90 | ADORA3 (0.50) | NT5ELMNAHIF1AAHCYADORA2A | |
| SCHEMBL23054709 | 0.90 | NT5E (0.61) | NT5ELMNAHIF1AAHCYADORA2A | |
| SCHEMBL749005 | 0.90 | ADORA3 (0.50) | NT5ELMNAHIF1AAHCYADORA2A | |
| SCHEMBL31307554 | 0.90 | NT5E (0.61) | NT5ELMNAHIF1AAHCYADORA2A | |
| SCHEMBL15964781 | 0.89 | ADORA2A (0.49) | NT5ELMNAHIF1AADORA2AADORA3 | |
| SCHEMBL745409 | 0.88 | ADORA3 (0.64) | NT5ELMNAADORA2AADORA3ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023178133-A9 | COMPOUNDS AND METHODS FOR TREATING DISEASE | ROME THERAPEUTICS, INC. (US) | 2023-10-26 | — | — | WO | disclosed |
| WO-2023178133-A1 | COMPOUNDS AND METHODS FOR TREATING DISEASE | ROME THERAPEUTICS, INC. (US) | 2023-09-21 | — | — | WO | disclosed |