Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24025481 | 1.00 | POLB (0.51) | POLBCHRM1ALDH1A1CYP2D6KDM4E | |
| SCHEMBL24025375 | 1.00 | POLB (0.51) | POLBCHRM1ALDH1A1CYP2D6KDM4E | |
| SCHEMBL24025372 | 0.82 | CHRM1 (0.54) | POLBCHRM1ALDH1A1CYP2D6CHRM5 | |
| SCHEMBL24025520 | 0.82 | CHRM1 (0.54) | POLBCHRM1ALDH1A1CYP2D6CHRM5 | |
| SCHEMBL24025469 | 0.81 | CHRM5 (0.60) | POLBCHRM1ALDH1A1CYP2D6CHRM5 | |
| SCHEMBL24057970 | 0.77 | POLB (0.67) | POLBCHRM1ALDH1A1CYP2D6KDM4E | |
| SCHEMBL24025480 | 0.76 | CHRM1 (0.61) | POLBCHRM1ALDH1A1CYP2D6KDM4E | |
| SCHEMBL24025466 | 0.75 | CHRM1 (0.57) | POLBCHRM1ALDH1A1CYP2D6KDM4E | |
| SCHEMBL24025623 | 0.75 | LMNA (0.56) | POLBALDH1A1GAAKMT2ALMNA | |
| SCHEMBL24058305 | 0.74 | POLB (0.56) | POLBCHRM1ALDH1A1CYP2D6KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3873600-B9 | PYRIDINYL SULFONAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | BOEHRINGER INGELHEIM INT (DE) | 2024-02-14 | — | — | EP | disclosed |
| EP-3873600-B1 | PYRIDINYL SULFONAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | BOEHRINGER INGELHEIM INT (DE) | 2023-09-20 | — | — | EP | disclosed |