Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 8/20 | 1.00 |
| ▸ | SOS1 | Q07889 | 2/20 | 0.51 |
| ▸ | BPTF | Q12830 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | FABP4 | P15090 | 4/20 | 0.32 |
| ▸ | FABP5 | Q01469 | 4/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26287230 | 0.85 | KRAS (0.74) | KRASSOS1FABP4FABP5CHRM2 | |
| SCHEMBL26287234 | 0.85 | KRAS (0.74) | KRASSOS1FABP4FABP5CHRM2 | |
| SCHEMBL25763213 | 0.77 | KRAS (0.61) | KRASSOS1BPTF | |
| SCHEMBL25768152 | 0.77 | KRAS (0.61) | KRASSOS1BPTF | |
| SCHEMBL31661616 | 0.74 | KRAS (0.59) | KRASSOS1 | |
| SCHEMBL24785070 | 0.74 | KRAS (1.00) | KRASSOS1BPTFALDH1A1GAA | |
| SCHEMBL24785888 | 0.72 | KRAS (0.73) | KRASSOS1BPTFALDH1A1GAA | |
| SCHEMBL29300344 | 0.71 | KRAS (0.71) | KRASSOS1BPTFALDH1A1GAA | |
| SCHEMBL29297692 | 0.70 | KRAS (0.91) | KRASSOS1BPTFALDH1A1GAA | |
| SCHEMBL24091400 | 0.70 | KRAS (0.69) | KRASSOS1BPTFALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023173017-A1 | KRAS INHIBITORS FOR TREATING DISEASE | BLOSSOMHILL THERAPEUTICS, INC. (US) | 2023-09-14 | — | — | WO | disclosed |