Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.44 |
| ▸ | PARP1 | P09874 | 2/20 | 0.43 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | DDO | Q99489 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.37 |
| ▸ | NQO2 | P16083 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24756943 | 0.81 | CYP1A2 (0.69) | CYP1A2KDM4EALDH1A1LMNAPDE3B | |
| SCHEMBL16740896 | 0.72 | ALDH1A1 (1.00) | CYP1A2KDM4EALDH1A1LMNACYP2C19 | |
| SCHEMBL6645443 | 0.72 | CYP1A2 (0.56) | CYP1A2KDM4EALDH1A1PDE3BPDE3A | |
| SCHEMBL588459 | 0.71 | ALDH1A1 (0.53) | CYP1A2KDM4EALDH1A1PARP1KMT2A | |
| SCHEMBL29353343 | 0.71 | ALDH1A1 (0.53) | CYP1A2KDM4EALDH1A1PARP1KMT2A | |
| Hydrochloric Acid SCHEMBL16740892 | 0.71 | ALDH1A1 (0.96) | CYP1A2KDM4EALDH1A1LMNACYP2C19 | |
| Formaldehyde SCHEMBL28821851 | 0.69 | CYP1A2 (0.52) | CYP1A2KDM4EALDH1A1PARP1DAO | |
| SCHEMBL598921 | 0.69 | CYP1A2 (0.52) | CYP1A2KDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL31607507 | 0.68 | TNKS2 (0.52) | CYP1A2LMNADAODDOCYP2C19 | |
| SCHEMBL8404581 | 0.67 | CYP1A2 (0.50) | CYP1A2ALDH1A1PARP1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024015262-A1 | FUSED RING KRAS INHIBITORS FOR TREATING DISEASE | BLOSSOMHILL THERAPEUTICS, INC. (US) | 2024-01-18 | — | — | WO | disclosed |
| WO-2023173017-A1 | KRAS INHIBITORS FOR TREATING DISEASE | BLOSSOMHILL THERAPEUTICS, INC. (US) | 2023-09-14 | — | — | WO | disclosed |
| WO-2023173016-A1 | KRAS INHIBITORS FOR TREATING DISEASE | BLOSSOMHILL THERAPEUTICS, INC. (US) | 2023-09-14 | — | — | WO | disclosed |
| WO-2023173014-A1 | KRAS INHIBITORS AND THEIR USE | BLOSSOMHILL THERAPEUTICS, INC. (US) | 2023-09-14 | — | — | WO | disclosed |