Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 3/20 | 0.34 |
| ▸ | PPOX | P50336 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4169053 | 0.90 | MEN1 (0.46) | MEN1KMT2AGAAFOXO1ALDH1A1 | |
| SCHEMBL4169061 | 0.90 | MEN1 (0.46) | MEN1KMT2AGAAFOXO1ALDH1A1 | |
| SCHEMBL14248206 | 0.88 | MEN1 (0.49) | MEN1KMT2AGAAFOXO1ALOX15 | |
| SCHEMBL262975 | 0.86 | MEN1 (0.50) | MEN1KMT2AGAAFOXO1ALDH1A1 | |
| SCHEMBL10146400 | 0.84 | MEN1 (0.50) | MEN1KMT2AGAAFOXO1ALDH1A1 | |
| SCHEMBL14248104 | 0.83 | MEN1 (0.49) | MEN1KMT2AGAAFOXO1ALDH1A1 | |
| SCHEMBL261963 | 0.80 | MEN1 (0.49) | MEN1KMT2AGAAFOXO1CNR1 | |
| SCHEMBL14247997 | 0.80 | MEN1 (0.49) | MEN1KMT2AGAAFOXO1ALOX15 | |
| SCHEMBL260972 | 0.80 | MEN1 (0.46) | MEN1KMT2AGAAFOXO1ALDH1A1 | |
| SCHEMBL14247912 | 0.80 | MEN1 (0.48) | MEN1KMT2AGAAFOXO1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133882-B2 | Quinolone derivative or pharmaceutically acceptable salt thereof | ASTELLAS PHARMA INC (JP) | 2012-03-13 | — | — | US | disclosed |
| EP-1995240-B1 | QUINOLONE DERIVATIVE OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF | ASTELLAS PHARMA INC (JP) | 2012-02-22 | — | — | EP | disclosed |