Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 3/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | DHODH | Q02127 | 5/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | CCR4 | P51679 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL262802 | 0.90 | MEN1 (0.48) | MEN1GAAKMT2AFOXO1PTGS1 | |
| SCHEMBL261426 | 0.89 | MEN1 (0.44) | MEN1GAAKMT2AFOXO1PPARA | |
| SCHEMBL14248140 | 0.87 | MEN1 (0.49) | MEN1GAAKMT2AFOXO1PTGS1 | |
| SCHEMBL14248142 | 0.87 | MEN1 (0.49) | MEN1GAAKMT2AFOXO1PTGS1 | |
| SCHEMBL263553 | 0.86 | MEN1 (0.47) | MEN1GAAKMT2AFOXO1PTGS1 | |
| SCHEMBL4170455 | 0.84 | MEN1 (0.49) | MEN1GAAKMT2AFOXO1PTGS1 | |
| SCHEMBL9277340 | 0.82 | GAA (0.48) | MEN1GAAKMT2AFOXO1MAPK1 | |
| SCHEMBL14248546 | 0.81 | MEN1 (0.48) | MEN1GAAKMT2AFOXO1PTGS1 | |
| SCHEMBL4171436 | 0.81 | MEN1 (0.47) | MEN1GAAKMT2AFOXO1PTGS1 | |
| SCHEMBL4171433 | 0.81 | MEN1 (0.47) | MEN1GAAKMT2AFOXO1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8133882-B2 | Quinolone derivative or pharmaceutically acceptable salt thereof | ASTELLAS PHARMA INC (JP) | 2012-03-13 | — | — | US | disclosed |