Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.48 |
| ▸ | IP6K1 | Q92551 | 2/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2877598 | 0.79 | MAP4K4 (0.51) | IP6K1 | |
| SCHEMBL496927 | 0.79 | PDE4A (0.48) | ALDH1A1KDM4EMEN1POLBKMT2A | |
| SCHEMBL2882274 | 0.78 | CYP1A2 (0.50) | ALDH1A1KDM4ESMN1; SMN2HPGDTSHR | |
| SCHEMBL2880423 | 0.78 | ALDH1A1 (0.43) | ALDH1A1KDM4EMEN1POLBKMT2A | |
| SCHEMBL31092634 | 0.78 | ALDH1A1 (0.43) | ALDH1A1KDM4EMEN1POLBKMT2A | |
| SCHEMBL2880252 | 0.78 | CYP1A2 (0.55) | ALDH1A1MEN1KMT2AHPGDCYP2A6 | |
| SCHEMBL13861996 | 0.78 | ALDH1A1 (0.38) | ALDH1A1KDM4EMEN1POLBKMT2A | |
| SCHEMBL3861852 | 0.76 | ALDH1A1 (0.45) | ALDH1A1KDM4EMEN1POLBKMT2A | |
| SCHEMBL29935762 | 0.75 | SMN1; SMN2 (0.47) | ALDH1A1KDM4EMEN1POLBKMT2A | |
| SCHEMBL4585191 | 0.75 | SMN1; SMN2 (0.47) | ALDH1A1KDM4EMEN1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230293519-A1 | INTEGRIN INHIBITORS AND USES THEREOF IN COMBINATION WITH OTHER AGENTS | PLIANT THERAPEUTICS INC (US) | 2023-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230293519-A1 | INTEGRIN INHIBITORS AND USES THEREOF IN COMBINATION WITH OTHER AGENTS | ITGB6, ITGA5, ITGAV | ALDH1A1 2893/4885KDM4E 3196/4885MEN1 3937/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.