Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Bendamustine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.92 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.92 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.92 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.92 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.92 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.92 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.92 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.92 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.92 |
| ▸ | RECQL | P46063 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | GMNN | O75496 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bendamustine SCHEMBL9950832 | 0.96 | HDAC6 (1.00) | HDAC6HDAC1HDAC3HDAC4HDAC2 | |
| Bendamustine SCHEMBL29394147 | 0.96 | HDAC6 (1.00) | HDAC6HDAC1HDAC3HDAC4HDAC2 | |
| Bendamustine SCHEMBL26319 | 0.96 | HDAC6 (1.00) | HDAC6HDAC1HDAC3HDAC4HDAC2 | |
| Bendamustine SCHEMBL15523734 | 0.95 | HDAC6 (0.98) | HDAC6HDAC1HDAC3HDAC4HDAC2 | |
| Bendamustine SCHEMBL18843 | 0.95 | HDAC6 (0.98) | HDAC6HDAC1HDAC3HDAC4HDAC2 | |
| Bendamustine SCHEMBL29352819 | 0.95 | HDAC6 (0.98) | HDAC6HDAC1HDAC3HDAC4HDAC2 | |
| Bendamustine SCHEMBL12497247 | 0.95 | HDAC6 (0.98) | HDAC6HDAC1HDAC3HDAC4HDAC2 | |
| Bendamustine SCHEMBL15436003 | 0.94 | HDAC6 (0.96) | HDAC6HDAC1HDAC3HDAC4HDAC2 | |
| Bendamustine SCHEMBL118499 | 0.94 | HDAC6 (0.96) | HDAC6HDAC1HDAC3HDAC4HDAC2 | |
| SCHEMBL16772708 | 0.93 | HDAC6 (0.94) | HDAC6HDAC1HDAC3HDAC4HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4135686-A1 | BASIC CHEMOTHERAPEUTIC INTRATUMOUR INJECTION FORMULATION | US Nano Food & Drug Inc (US) | 2023-02-22 | — | — | EP | claimed |
| CN-114929213-A | Alkaline chemotherapeutic intratumoral injection composition | 美国纳米食品药品公司 | 2022-08-19 | — | — | CN | claimed |
| WO-2021211294-A1 | BASIC CHEMOTHERAPEUTIC INTRATUMOUR INJECTION FORMULATION | US Nano Food & Drug INC (US) | 2021-10-21 | — | — | WO | claimed |
| US-20210315913-A1 | BASIC CHEMOTHERAPEUTIC INTRATUMOUR INJECTION FORMULATION | US Nano Food & Drug, Inc (US) | 2021-10-14 | — | — | US | claimed |
| US-11752165-B2 | Basic chemotherapeutic intratumour injection formulation | US Nano Food & Drug, Inc (US) | 2023-09-12 | — | — | US | disclosed |
| EP-4135686-A1 | BASIC CHEMOTHERAPEUTIC INTRATUMOUR INJECTION FORMULATION | US Nano Food & Drug Inc (US) | 2023-02-22 | — | — | EP | disclosed |
| CN-114929213-A | Alkaline chemotherapeutic intratumoral injection composition | 美国纳米食品药品公司 | 2022-08-19 | — | — | CN | disclosed |
| WO-2021211294-A1 | BASIC CHEMOTHERAPEUTIC INTRATUMOUR INJECTION FORMULATION | US Nano Food & Drug INC (US) | 2021-10-21 | — | — | WO | disclosed |
| US-20210315913-A1 | BASIC CHEMOTHERAPEUTIC INTRATUMOUR INJECTION FORMULATION | US Nano Food & Drug, Inc (US) | 2021-10-14 | — | — | US | disclosed |