Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.44 |
| ▸ | TEAD1 | P28347 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3478794 | 1.00 | EPHX1 (0.52) | EPHX1POLBSMYD3TEAD1RAB9A | |
| SCHEMBL2618960 | 1.00 | EPHX1 (0.52) | EPHX1POLBSMYD3TEAD1RAB9A | |
| SCHEMBL9624068 | 0.89 | POLB (0.54) | EPHX1POLBSMYD3TEAD1RAB9A | |
| SCHEMBL308515 | 0.89 | — | — | |
| SCHEMBL24244484 | 0.88 | EPHX1 (0.40) | EPHX1POLBSMYD3TEAD1ALDH1A1 | |
| SCHEMBL20892801 | 0.88 | EPHX1 (0.40) | EPHX1POLBSMYD3TEAD1ALDH1A1 | |
| SCHEMBL20892953 | 0.88 | EPHX1 (0.40) | EPHX1POLBSMYD3TEAD1ALDH1A1 | |
| SCHEMBL20892805 | 0.88 | EPHX1 (0.40) | EPHX1POLBSMYD3TEAD1ALDH1A1 | |
| SCHEMBL19353226 | 0.88 | EPHX1 (0.40) | EPHX1POLBSMYD3TEAD1ALDH1A1 | |
| SCHEMBL19353270 | 0.88 | EPHX1 (0.40) | EPHX1POLBSMYD3TEAD1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3544970-B1 | INHIBITORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES AND USES THEREOF | DANA FARBER CANCER INST INC (US) | 2021-11-17 | — | — | EP | disclosed |
| WO-2021000957-A1 | HETEROCYCLIC COMPOUND AND PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF | 北京国鸿生物医药科技有限公司 | 2021-01-07 | — | — | WO | disclosed |
| US-10870652-B2 | Compounds and methods for modulating bruton's tyrosine kinase | CORVUS PHARMACEUTICALS, INC. (US) | 2020-12-22 | — | — | US | disclosed |
| US-20190106423-A1 | COMPOUNDS AND METHODS FOR MODULATING BRUTON'S TYROSINE KINASE | CORVUS BIOPHARMACEUTICALS, LTD. (KY) | 2019-04-11 | — | — | US | disclosed |
| WO-2018098367-A1 | INHIBITORS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES AND USES THEREOF | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-05-31 | — | — | WO | disclosed |
| US-9951077-B2 | Aminopyridazinone compounds as protein kinase inhibitors | JIANGSU HENGRUI MEDICINE CO., LTD. (CN) | 2018-04-24 | — | — | US | disclosed |
| EP-2529622-B1 | Inhibitors of bruton's tyrosine kinase | PHARMACYCLICS LLC (US) | 2018-01-17 | — | — | EP | disclosed |
| EP-2307025-B1 | INHIBITORS OF BRUTON'S TYROSINE KINASE FOR THE TREATMENT OF SOLID TUMORS | PHARMACYCLICS LLC (US) | 2017-09-20 | — | — | EP | disclosed |
| WO-2017156495-A1 | COMPOUNDS AND METHODS FOR MODULATING BRUTON'S TYROSINE KINASE | CORVUS PHARMACEUTICALS, INC. (US) | 2017-09-14 | — | — | WO | disclosed |
| US-20170152264-A1 | AMINOPYRIDAZINONE COMPOUNDS AS PROTEIN KINASE INHIBITORS | Eternity Bioscience Inc. (US) | 2017-06-01 | — | — | US | disclosed |
| EP-2042564-A1 | Photocurable coating composition, and overprint and process for producing same | FUJIFILM Corporation (JP) | 2009-04-01 | — | — | EP | disclosed |
| US-20090081422-A1 | PHOTOCURABLE COATING COMPOSITION, AND OVERPRINT AND PROCESS FOR PRODUCING SAME | FUJIFILM CORPORATION (JP) | 2009-03-26 | — | — | US | disclosed |
| US-20090081422-A1 | PHOTOCURABLE COATING COMPOSITION, AND OVERPRINT AND PROCESS FOR PRODUCING SAME | FUJIFILM CORPORATION (JP) | 2009-03-26 | — | — | US | disclosed |
| EP-1927477-B1 | Ink composition for inkjet-recording and method for inkjet-recording | FUJIFILM CORP (JP) | 2009-03-18 | — | — | EP | disclosed |
| US-20080131618-A1 | INK COMPOSITION FOR INKJET-RECORDING AND METHOD FOR INKJET-RECORDING | FUJIFILM CORPORATION (JP) | 2008-06-05 | — | — | US | disclosed |
| US-20080131618-A1 | INK COMPOSITION FOR INKJET-RECORDING AND METHOD FOR INKJET-RECORDING | FUJIFILM CORPORATION (JP) | 2008-06-05 | — | — | US | disclosed |
| EP-1927477-A1 | Ink composition for inkjet-recording and method for inkjet-recording | FUJIFILM Corporation (JP) | 2008-06-04 | — | — | EP | disclosed |
| US-20070115327-A1 | Ink composition, ink jet recording method, method for producing planographic printing plate and planographic printing plate | FUJIFILM CORPORATION | 2007-05-24 | — | — | US | disclosed |
| US-20070115327-A1 | Ink composition, ink jet recording method, method for producing planographic printing plate and planographic printing plate | FUJIFILM CORPORATION | 2007-05-24 | — | — | US | disclosed |
| EP-1788045-A1 | Ink composition, ink jet recording method for producing planographic printing plate and planographic printing plate | Fujifilm Corporation (JP) | 2007-05-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190106423-A1 | COMPOUNDS AND METHODS FOR MODULATING BRUTON'S TYROSINE KINASE | ABL1, BTK, LYN | EPHX1 2312/4885POLB 1813/4885SMYD3 1193/4885 |
| US-20170152264-A1 | AMINOPYRIDAZINONE COMPOUNDS AS PROTEIN KINASE INHIBITORS | SSB, MAPKAPK5, BCL9 | EPHX1 4468/4885POLB 2202/4885SMYD3 1510/4885 |
| US-10870652-B2 | Compounds and methods for modulating bruton's tyrosine kinase | ABL1, BTK, LYN | EPHX1 2312/4885POLB 1813/4885SMYD3 1193/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.