Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.42 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.42 |
| ▸ | EP300 | Q09472 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.36 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24113377 | 0.79 | ALOX15 (0.45) | BRD4CREBBPBRPF1EP300ALOX15 | |
| SCHEMBL281598 | 0.76 | ALOX15 (0.50) | BRD4CREBBPBRPF1ALOX15PTPN11 | |
| SCHEMBL19173476 | 0.71 | ALOX15 (0.40) | BRD4CREBBPBRPF1EP300ALOX15 | |
| SCHEMBL30147558 | 0.69 | KMT2A (0.43) | BRD4CREBBPALOX15KMT2ANUDT1 | |
| SCHEMBL30689209 | 0.68 | ALOX15 (0.42) | BRD4CREBBPBRPF1ALOX15PTPN11 | |
| SCHEMBL12846301 | 0.67 | KDM4E (0.69) | ALOX15PLK1KMT2AMAPTNPC1 | |
| SCHEMBL2315045 | 0.66 | — | — | |
| SCHEMBL13488601 | 0.66 | KMT2A (0.72) | ALOX15KMT2AMAPTNPC1KDM4E | |
| SCHEMBL22502874 | 0.66 | CHEK1 (0.53) | BRD4CREBBPPLK1USP2CHEK1 | |
| SCHEMBL16543122 | 0.65 | CYP1A2 (0.61) | BRD4CREBBPALOX15PTPN11KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4234552-A2 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | Raze Therapeutics, Inc. (US) | 2023-08-30 | — | — | EP | disclosed |