Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 20/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | RPTOR | Q8N122 | 6/20 | 0.45 |
| ▸ | MLST8 | Q9BVC4 | 6/20 | 0.45 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.44 |
| ▸ | RICTOR | Q6R327 | 4/20 | 0.44 |
| ▸ | MAPKAP1 | Q9BPZ7 | 4/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.44 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3227470 | 0.87 | MTOR (0.51) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| SCHEMBL8367412 | 0.85 | MTOR (0.50) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| SCHEMBL1833561 | 0.85 | MTOR (0.51) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| SCHEMBL1833563 | 0.85 | MTOR (0.51) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| SCHEMBL15196055 | 0.85 | MTOR (0.54) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| Hydrochloric Acid SCHEMBL1832259 | 0.84 | MTOR (0.51) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| Hydrochloric Acid SCHEMBL1832255 | 0.84 | MTOR (0.51) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| SCHEMBL2625406 | 0.83 | MTOR (0.46) | MTORPIK3CACYP3A4KCNH2RPTOR | |
| SCHEMBL2632788 | 0.83 | MTOR (0.62) | MTORPIK3CA | |
| SCHEMBL7945032 | 0.83 | MTOR (0.58) | MTORPIK3CACYP3A4KCNH2RPTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120165313-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2012-06-28 | — | — | US | disclosed |
| US-20120165313-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2012-06-28 | — | — | US | disclosed |
| US-8163763-B2 | Pyrimidine compounds, compositions and methods of use | GENENTECH, INC. (US) | 2012-04-24 | — | — | US | disclosed |
| US-20100069357-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2010-03-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165313-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | MTOR, TYMS, DTYMK | MTOR 1/4885PIK3CA 4/4885CYP3A4 1677/4885 |
| US-20100069357-A1 | PYRIMIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | MTOR, TYMS, DTYMK | MTOR 1/4885PIK3CA 4/4885CYP3A4 1677/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.