Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.52 |
| ▸ | TMEM97 | Q5BJF2 | 6/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.52 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.45 |
| ▸ | DPP9 | Q86TI2 | 4/20 | 0.45 |
| ▸ | DPP7 | Q9UHL4 | 4/20 | 0.45 |
| ▸ | DPP4 | P27487 | 3/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12382091 | 0.86 | KCNH2 (0.47) | KCNH2TMEM97SIGMAR1DPP8DPP9 | |
| SCHEMBL9963386 | 0.84 | KCNH2 (0.50) | KCNH2TMEM97SIGMAR1DPP8DPP9 | |
| SCHEMBL22817021 | 0.82 | DRD1 (0.47) | HRH3 | |
| SCHEMBL10311216 | 0.82 | HTR2A (0.43) | KCNH2TMEM97SIGMAR1HTR7HRH3 | |
| SCHEMBL2632898 | 0.82 | HTR2A (0.43) | KCNH2TMEM97SIGMAR1HTR7HRH3 | |
| SCHEMBL2632966 | 0.79 | MAOA (0.50) | HRH3KMT2A | |
| SCHEMBL20756303 | 0.79 | MAOA (0.50) | HRH3KMT2A | |
| SCHEMBL7894841 | 0.78 | KCNH2 (0.50) | KCNH2TMEM97SIGMAR1DPP8DPP9 | |
| SCHEMBL23102118 | 0.76 | ACACB (0.44) | KCNH2TMEM97SIGMAR1HTR7TRPV3 | |
| SCHEMBL13713708 | 0.75 | MAOB (0.56) | HRH3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8163720-B2 | Pyrrolidinyl phenyl sulphonamides as modulators of ion channels | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-04-24 | — | — | US | disclosed |